Sulfo-NHS-Acetate

Name: Sulfo-NHS-Acetate
Brand: MedChemExpress
SKU: HY-140341
Rating: 4.5 (0 reviews)

Cat. No.: HY-140341 Pureza: 98.0%: Ficha de datos
COA

SDS
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Sulfo-NHS-Acetate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Para uso exclusivo en investigación. No vendemos a pacientes.

Sulfo-NHS-Acetate Estructura química

No. CAS : 152305-87-8

Tamaño	Stock	Cantidad
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
1 g	En stock	Estimated Time of Arrival: December 31
5 g	Obtener un presupuesto
10 g	Obtener un presupuesto

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Based on 1 Customer Validation

Other Forms of Sulfo-NHS-Acetate:

Sulfo-NHS-Acetate sodium In-stock

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas PROTAC Linkers:

Ver todas las isoformas

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Sulfo-NHS-Acetate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

Alkyl-Chain

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

237.19

Fòrmula

C₆H₇NO₇S

No. CAS

152305-87-8

Appearance

Solid

Color

White to off-white

SMILES

O=S(C(C1)C(N(OC(C)=O)C1=O)=O)(O)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (527.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2160 mL	21.0801 mL	42.1603 mL
5 mM	0.8432 mL	4.2160 mL	8.4321 mL
10 mM	0.4216 mL	2.1080 mL	4.2160 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98%

Select Batch:

Ficha de datos (274 KB) SDS (393 KB)

COA (252 KB) HNMR (130 KB) MS (304 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.2160 mL	21.0801 mL	42.1603 mL	105.4007 mL
	5 mM	0.8432 mL	4.2160 mL	8.4321 mL	21.0801 mL
	10 mM	0.4216 mL	2.1080 mL	4.2160 mL	10.5401 mL
	15 mM	0.2811 mL	1.4053 mL	2.8107 mL	7.0267 mL
	20 mM	0.2108 mL	1.0540 mL	2.1080 mL	5.2700 mL
	25 mM	0.1686 mL	0.8432 mL	1.6864 mL	4.2160 mL
	30 mM	0.1405 mL	0.7027 mL	1.4053 mL	3.5134 mL
	40 mM	0.1054 mL	0.5270 mL	1.0540 mL	2.6350 mL
	50 mM	0.0843 mL	0.4216 mL	0.8432 mL	2.1080 mL
	60 mM	0.0703 mL	0.3513 mL	0.7027 mL	1.7567 mL
	80 mM	0.0527 mL	0.2635 mL	0.5270 mL	1.3175 mL
	100 mM	0.0422 mL	0.2108 mL	0.4216 mL	1.0540 mL