TC-2559 

TC-2559 is an orally active, selective central nervous system Nicotinic acetylcholine receptor agonist with a K_i value of 5 nM. TC-2559 activates central nervous system receptors selectively over peripheral nervous system receptors. TC-2559 improves scopolamine (HY-N0296)-induced cognitive impairment and enhances radial arm maze performance. TC-2559 can be used in the research of neurodegenerative diseases^[1].

TC-2559 binds with high affinity to nicotinic acetylcholine receptors in rat brain cortex membranes, with a K_i of 5.5 nM^[1].
TC-2559 (0.01-100 μM) potently and efficaciously stimulates dopamine release from rat striatal synaptosomes (EC₅₀ = 203 nM) and induces significantly less residual inhibition of dopamine release than nicotine following pre-incubation^[1].
TC-2559 (0.01-90 μM) potently stimulates ⁸⁶Rb⁺ efflux from rat thalamic synaptosomes, with an EC₅₀ of 367 nM and efficacy comparable to nicotine^[1].
TC-2559 (10 μM; 2 h) significantly protects cultured fetal rat brain cells from glutamate-induced neurotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TC-2559 (3-6 μmol/kg; subcutaneous injection; single administration) significantly reverses scopolamine-induced cognitive impairment in male Sprague-Dawley rats in the step-through passive avoidance test^[1].
TC-2559 (1-10 μmol/kg; p.o.; single administration or daily administration for 6 consecutive days) enhances radial arm maze working memory performance in male Sprague-Dawley rats (acute administration), improves their reference memory at an acute dose of 1 μmol/kg, and repeated oral administration (1-6 μmol/kg) further enhances their working memory performance^[1].
TC-2559 (1-10 μmol/kg; subcutaneous injection; single administration) induces dose-dependent hypoactivity in male Sprague-Dawley rats. A dose of 1 μmol/kg produces a persistent effect, and both 1 μmol/kg and 10 μmol/kg doses significantly reduce locomotor activity over 30 minutes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

311.30

C₁₂H₁₈N₂O·1/2C₆H₁₀O₈

326924-19-0

OC([C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C(O)=O)=O.CNCC/C=C/C1=CN=CC(OCC)=C1.[1/2]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bencherif M, et al. TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur J Pharmacol. 2000;409(1):45-55.  [Content Brief]