Tetraethylene glycol monomethyl ether

Name: Tetraethylene glycol monomethyl ether
Brand: MedChemExpress
SKU: HY-W018365
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Cat. No.: HY-W018365 Pureza: 98.0%: Ficha de datos
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Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Tetraethylene glycol monomethyl ether Estructura química

No. CAS : 23783-42-8

Tamaño	Stock	Cantidad
25 g	En stock	Estimated Time of Arrival: December 31
50 g	En stock	Estimated Time of Arrival: December 31
100 g	En stock	Estimated Time of Arrival: December 31
250 g	En stock	Estimated Time of Arrival: December 31
500 g	En stock	Estimated Time of Arrival: December 31
1 kg	En stock	Estimated Time of Arrival: December 31

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Based on 1 Customer Validation

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas PROTAC Linkers:

Ver todas las isoformas

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

208.25

Fòrmula

C₉H₂₀O₅

No. CAS

23783-42-8

Appearance

Liquid (Density: 1.045 g/cm³)

Color

Colorless to light yellow

SMILES

COCCOCCOCCOCCO

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

H₂O : ≥ 100 mg/mL (480.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8019 mL	24.0096 mL	48.0192 mL
5 mM	0.9604 mL	4.8019 mL	9.6038 mL
10 mM	0.4802 mL	2.4010 mL	4.8019 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.35%

Select Batch:

Ficha de datos (266 KB) SDS (394 KB)

COA (239 KB) HNMR (122 KB) GC (79 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.8019 mL	24.0096 mL	48.0192 mL	120.0480 mL
	5 mM	0.9604 mL	4.8019 mL	9.6038 mL	24.0096 mL
	10 mM	0.4802 mL	2.4010 mL	4.8019 mL	12.0048 mL
	15 mM	0.3201 mL	1.6006 mL	3.2013 mL	8.0032 mL
	20 mM	0.2401 mL	1.2005 mL	2.4010 mL	6.0024 mL
	25 mM	0.1921 mL	0.9604 mL	1.9208 mL	4.8019 mL
	30 mM	0.1601 mL	0.8003 mL	1.6006 mL	4.0016 mL
	40 mM	0.1200 mL	0.6002 mL	1.2005 mL	3.0012 mL
	50 mM	0.0960 mL	0.4802 mL	0.9604 mL	2.4010 mL
	60 mM	0.0800 mL	0.4002 mL	0.8003 mL	2.0008 mL
	80 mM	0.0600 mL	0.3001 mL	0.6002 mL	1.5006 mL
	100 mM	0.0480 mL	0.2401 mL	0.4802 mL	1.2005 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.