2. Epigenetics
  3. HuR
  4. TM11

TM11, a Tanshinone mimic, is a potent HuR inhibitor that can inhibit HuR-RNA complex formation. TM11 reduces LPS-induced inflammatory response in murine macrophages.

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TM11

TM11 構造式

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1870 在庫あり
Solution
10 mM * 1 mL in DMSO USD 1870 在庫あり
Solid
1 mg $680 在庫あり
5 mg $1700 在庫あり
10 mg $2700 在庫あり
25 mg $5400 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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TM11 関連抗体

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製品説明

TM11, a Tanshinone mimic, is a potent HuR inhibitor that can inhibit HuR-RNA complex formation. TM11 reduces LPS-induced inflammatory response in murine macrophages[1].

分子量

353.35

分子式

C18H11NO5S
Appearance

Solid

Color

Dark purple to black

SMILES

O=C1C2=C(N(S(=O)(C3=CC=CC=C3)=O)C=C2C4=CC=CO4)C=CC1=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (141.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8301 mL 14.1503 mL 28.3006 mL
5 mM 0.5660 mL 2.8301 mL 5.6601 mL
10 mM 0.2830 mL 1.4150 mL 2.8301 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8301 mL 14.1503 mL 28.3006 mL 70.7514 mL
5 mM 0.5660 mL 2.8301 mL 5.6601 mL 14.1503 mL
10 mM 0.2830 mL 1.4150 mL 2.8301 mL 7.0751 mL
15 mM 0.1887 mL 0.9434 mL 1.8867 mL 4.7168 mL
20 mM 0.1415 mL 0.7075 mL 1.4150 mL 3.5376 mL
25 mM 0.1132 mL 0.5660 mL 1.1320 mL 2.8301 mL
30 mM 0.0943 mL 0.4717 mL 0.9434 mL 2.3584 mL
40 mM 0.0708 mL 0.3538 mL 0.7075 mL 1.7688 mL
50 mM 0.0566 mL 0.2830 mL 0.5660 mL 1.4150 mL
60 mM 0.0472 mL 0.2358 mL 0.4717 mL 1.1792 mL
80 mM 0.0354 mL 0.1769 mL 0.3538 mL 0.8844 mL
100 mM 0.0283 mL 0.1415 mL 0.2830 mL 0.7075 mL
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TM11 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TM11TM 11TM-11HuRHuman Antigen RHuR-RNA complexLPSmacrophagesInhibitorinhibitorinhibit

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製品番号:
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