Transketolase-IN-6 

Transketolase-IN-6 is a potent transketolase inhibitor and a herbicide. Transketolase-IN-6 inhibits root growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis. Transketolase-IN-6 shows low phytotoxicity to wheat, maize, soybean, and cotton. Transketolase-IN-6 can be used for the research of herbicidal agent development^[1].

Transketolase-IN-6 (compound 6bj) (200 mg/L; 7 days) potently inhibits root and stem growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis, with root inhibition rates of 89.5%, 77.2%, and 77.4% respectively^[1].
Transketolase-IN-6 (150 g ai/ha; 7 days) inhibits post-emergence growth of Digitaria sanguinalis, Amaranthus retroflexus, and Setaria viridis by 80.2%, 75.0%, and 82.3% respectively, with GR₅₀ values ranging from 60.372 to 96.768 g ai/ha^[1].
Transketolase-IN-6 (150-300 g ai/ha) is safe for wheat, maize, soybean, and cotton at 150 g ai/ha (injury <10%) and causes <25% injury at 300 g ai/ha^[1].
Transketolase-IN-6 binds strongly to Arabidopsis thaliana transketolase with a binding free energy of 6.394 kcal/mol via multiple hydrogen bond, π−cation, and π−π T-shaped interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

436.94

C₂₃H₂₅ClN₆O

ClC1=C(N2N=CC(C(NCC3=CC=CN=C3)=O)=C2N(CC4CC4)CC5CC5)N=CC=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hu S, et al. Design, Synthesis, and Herbicidal Activity of Pyrazole Amide Derivatives as Potential Transketolase Inhibitors. J Agric Food Chem. 2024;72(7):3334-3341.  [Content Brief]