2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. Trypsin-IN-2

Trypsin-IN-2 (Compound 12) is an efficient and highly selective inhibitor of human trypsin, with an IC₅₀ of 8 nM. Trypsin-IN-2 can be used for research on pancreatic cancer.

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Trypsin-IN-2

Trypsin-IN-2 Chemische Struktur

CAS. Nr. : 1984788-85-3

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Trypsin-IN-2 Related Antibodies

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Beschreibung

Trypsin-IN-2 (Compound 12) is an efficient and highly selective inhibitor of human trypsin, with an IC₅₀ of 8 nM. Trypsin-IN-2 can be used for research on pancreatic cancer[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
30 3
Compound: 12
Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assay
Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assay
[PMID: 27476144]
HEK293 IC50
>30 3
Compound: 12
Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assay
Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assay
[PMID: 27476144]
Molekulargewicht

496.60

Formel

C27H36N4O5
CAS. Nr.
SMILES

O=C(C1=CC(OC)=C(C=C1)CN)N2C[C@@H](N3CC4=CC=CC(OCCOC)=C4CC3)C[C@H]2C(NC)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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Trypsin-IN-2 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trypsin-IN-21984788-85-3Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesTrypsin inhibitorPancreatitishERG inhibitionProtease selectivityPharmacokineticsX-ray crystal structureStructure-activity relationshipInhibitorinhibitorinhibit

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