Tubulin inhibitor 17

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Tubulin inhibitor 17 (Compound 3b) is a tubulin polymerization inhibitor with an IC₅₀ of 12.38 µM. Tubulin inhibitor 17 has anticancer activities and induces cell apoptosis.

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Tubulin inhibitor 17 화학구조

CAS No. : 2839151-13-0

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Tubulin inhibitor 17 (Compound 3b) is a tubulin polymerization inhibitor with an IC₅₀ of 12.38 µM. Tubulin inhibitor 17 has anticancer activities and induces cell apoptosis^[1].

IC₅₀ & Target

IC₅₀: 12.38 µM (tubulin polymerization)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
B16-F10	IC₅₀	0.563 3 Compound: 3b	Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
B16-F10	IC₅₀	0.563 3 Compound: 3b	Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
HeLa	IC₅₀	2.047 3 Compound: 3b	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
HeLa	IC₅₀	2.047 3 Compound: 3b	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
HepG2	IC₅₀	0.261 3 Compound: 3b	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
MCF7	IC₅₀	0.609 3 Compound: 3b	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
HepG2	IC₅₀	0.261 3 Compound: 3b	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]
MCF7	IC₅₀	0.609 3 Compound: 3b	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 34455231]

In Vitro

Tubulin inhibitor 17 (Compound 3b) (0-10 µM, 0-72 h) displays antiproliferative activities against cancer cells and inhibits colony formation of HepG-2 cells^[1].
Tubulin inhibitor 17 (0-2.5 µM) inhibits tubulin polymerization in a concentration-dependent manner^[1].
Tubulin inhibitor 17 (0-1 µM, 12 h) induces the collapse of the microtubule networks in a dose-dependent manner^[1].
Tubulin inhibitor 17 (0-5 μM, 24 h) induces cell cycle arrest at G2/M phase and inhibits cell migration in HepG-2 cells^[1].
Tubulin inhibitor 17 (0-5 μM, 48 h) induces HepG-2 cell apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	B16-F10, HepG-2, Hela and MCF-7
Concentration:	0, 0.5, 2.5, 5.0, 7.5 and 10 µM
Incubation Time:	48 h for IC₅₀ measurement, 0-72 h for cell viability
Result:	Displayed antiproliferative activities with IC₅₀ values of 0.563 ± 0.099, 0.261 ± 0.025, 2.047 ± 0.168 and 0.609 ± 0.062 µM against B16-F10, HepG-2, Hela and MCF-7 cells, respectively. Inhibited the cell viability in a time- and concentration- dependent manner.

Cell Cycle Analysis^[1]

Cell Line:	HepG-2
Concentration:	0.5, 1.0 and 5.0 μM
Incubation Time:	24 h
Result:	Dose-dependently induced cell cycle arrest at G2/M phase.

Apoptosis Analysis^[1]

Cell Line:	HepG-2
Concentration:	0.5, 1.0 and 5.0 μM
Incubation Time:	48 h
Result:	The total proportion of apoptotic cells were increased significantly compared with the control.

분자량

264.32

화학식

C₁₇H₁₆N₂O

CAS No.

2839151-13-0

SMILES

COC1=CC=C(C=C1)N(C2=CC=CC3=NC=CC=C23)C

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ren Y, et al. Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities. Bioorg Med Chem. 2021 Sep 15;46:116376. [Content Brief]