[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat

Name: [Tyr22] Calcitonin Gene Related Peptide, (22-37), rat
Brand: MedChemExpress
SKU: HY-P3689
Rating: 4.5 (1 reviews)

Cat. No.: HY-P3689 Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

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[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat is a fragments 22-37 of rat calcitonin gene related peptide (CGRP), targeting CGRP receptor and adenylate cyclase. Calcitonin is mainly produced by thyroid C cells while CGRP is secreted and stored in the nervous system.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat Chemical Structure

CAS No. : 198277-54-2

Size	Price	Stock	Quantity
1 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 208	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 354	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Calcitonin Gene Related Peptide (CGRP) in humans, exists in two forms: CGRP alpha (α-CGRP or CGRP I), and CGRP beta (β-CGRP or CGRP II)^[2].
[Tyr22] Calcitonin Gene Related Peptide, (22-37), rat shows the receptor binding affinity mainly depending on the carboxyterminal end while the ability to stimulate adenylate cyclase (AC) enzyme mainly depending on the aminoterminal end^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1785.95

Formula

C₈₂H₁₂₀N₂₀O₂₅

CAS No.

198277-54-2

Appearance

Solid

Color

White to off-white

Sequence

Tyr-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2

Sequence Shortening

YVKDNFVPTNVGSEAF-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (55.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.5599 mL	2.7996 mL	5.5993 mL
5 mM	0.1120 mL	0.5599 mL	1.1199 mL
10 mM	0.0560 mL	0.2800 mL	0.5599 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (243 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Jia S, et al. Calcitonin gene-related peptide enhances osteogenic differentiation and recruitment of bone marrow mesenchymal stem cells in rats. Exp Ther Med. 2019 Aug;18(2):1039-1046. [Content Brief]

[2]. Russell FA, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94(4):1099-142. [Content Brief]

[3]. Heino P, et al. Binding of CGRP analogs and their effect on adenylate cyclase activity in porcine iris-ciliary body. J Ocul Pharmacol Ther. 1998 Dec;14(6):543-54. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.5599 mL	2.7996 mL	5.5993 mL	13.9982 mL
	5 mM	0.1120 mL	0.5599 mL	1.1199 mL	2.7996 mL
	10 mM	0.0560 mL	0.2800 mL	0.5599 mL	1.3998 mL
	15 mM	0.0373 mL	0.1866 mL	0.3733 mL	0.9332 mL
	20 mM	0.0280 mL	0.1400 mL	0.2800 mL	0.6999 mL
	25 mM	0.0224 mL	0.1120 mL	0.2240 mL	0.5599 mL
	30 mM	0.0187 mL	0.0933 mL	0.1866 mL	0.4666 mL
	40 mM	0.0140 mL	0.0700 mL	0.1400 mL	0.3500 mL
	50 mM	0.0112 mL	0.0560 mL	0.1120 mL	0.2800 mL