2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. α-Glucosidase-IN-98

α-Glucosidase-IN-98 is a potent orally active α-Glucosidase inhibitor with an IC50 of 18.1 μM. α-Glucosidase-IN-98 reversibly binds with α-Glucosidase via hydrogen bonds, electrostatic interactions and hydrophobic effects, which induces significant conformational alterations in the secondary structure of α-Glucosidase. α-Glucosidase-IN-98 decreases postprandial hyperglycemia in Starch (HY-B2225B)/Sucrose (HY-B1779)-challenged mice. α-Glucosidase-IN-98 can be used for type 2 diabetes mellitus (T2DM) research.

For research use only. We do not sell to patients.

α-Glucosidase-IN-98

α-Glucosidase-IN-98 Chemical Structure

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α-Glucosidase-IN-98 Related Antibodies

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Description

α-Glucosidase-IN-98 is a potent orally active α-Glucosidase inhibitor with an IC50 of 18.1 μM. α-Glucosidase-IN-98 reversibly binds with α-Glucosidase via hydrogen bonds, electrostatic interactions and hydrophobic effects, which induces significant conformational alterations in the secondary structure of α-Glucosidase. α-Glucosidase-IN-98 decreases postprandial hyperglycemia in Starch (HY-B2225B)/Sucrose (HY-B1779)-challenged mice. α-Glucosidase-IN-98 can be used for type 2 diabetes mellitus (T2DM) research[1].

IC50 & Target[1]

α‑glucosidase

18.1 μM (IC50)

In Vitro

α-Glucosidase-IN-98 (compound 5c) maintains strong α-Glucosidase inhibitory activity in the presence of polysaccharides (Acacia gum (HY-N6664), Pectin (HY-W145518)), unlike with proteins, fatty acids, or PEG, which cause significant attenuation[1].
α-Glucosidase-IN-98 (0-40 μM) reversibly inhibits α-Glucosidase via non-covalent interactions, exhibiting a higher binding affinity for the enzyme-substrate complex (Ki = 13.9 μM) than for the free enzyme (Ki = 42.2 μM)[1].
α-Glucosidase-IN-98 binds with α-Glucosidase mainly through hydrogen bonds (with Asp69, Asp352, His280), electrostatic interactions (with Asp215, Asp315), and hydrophobic interactions (with Val216), consistent with the static quenching[1].
α-Glucosidase-IN-98 (0-46.4 μM) reduces the surface hydrophobicity of α-Glucosidase by 29.4%, and induces a structural shift (decreased α-helix, increased β-sheet) that enhances rigidity, suggesting that it can stabilize the enzyme by occupying the hydrophobic cavity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Glucosidase-IN-98 Related Antibodies
In Vivo

α-Glucosidase-IN-98 (10, 20 and 40 mg/kg, p.o., single dose) dose-dependently attenuates postprandial hyperglycemia in starch/sucrose-challenged mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Kunming mice (7 weeks) with postprandial hyperglycemia induced by acute high-dose (3 g/kg) starch administration[1]
Dosage: 10, 20 and 40 mg/kg
Administration: p.o., single dose
Result: Showed dose-dependent hypoglycemic effects.
Demonstrated progressively reduction in glycemic AUCs by 23.4%, 25.7%, and 29.4%, at 10, 20 and 40 mg/kg, respectively.
Resulted in lower blood glucose curves than the control group, demonstrating a notable delay in carbohydrate breakdown and absorption.
Animal Model: Male Kunming mice (7 weeks) with postprandial hyperglycemia induced by acute high-dose (3 g/kg) sucrose administration[1]
Dosage: 10, 20 and 40 mg/kg
Administration: p.o., single dose
Result: Displayed a dose-dependent decrease in AUC, with reductions of 10.5%, 15.8%, and 21.7%, at 10, 20, and 40 mg/kg, respectively.
Alleviated sucrose-induced postprandial hyperglycemia via α-Glucosidase inhibition.
Molecular Weight

309.36

Formula

C19H19NO3
SMILES

COC1=CC(CCC(CCC2=CC=C(C=C2)C#N)=O)=CC=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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α-Glucosidase-IN-98 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-98Glycosidaseα-Glucosidasepostprandial hyperglycemiastarch/sucrose-challenged miceT2DMInhibitorinhibitorinhibit

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