α-Eleostearic acid  (Synonyms: cis-Eleostearic acid)

α-Eleostearic acid (cis-Eleostearic acid), a conjugated linolenic acid, is an apoptosis inducer. α-Eleostearic acid is also a ferroptosis inducer. α-Eleostearic acid exhibits antioxidant and antitumor activity^[1][2][3].

α-Eleostearic acid (0-40 μM; 24 h) inhibits the growth of some cancer and fibroblast cell lines, including those of HL60 leukemia and HT29 colon carcinoma^[1].
α-Eleostearic acid (20 μM; 6 h) induced cellular and nuclear fragmentation, and nucleosomal DNA fragmentation typical of apoptosis in HL60 leukemia cells^[1].
α-Eleostearic acid (0.01-100 μM; 72 h) triggers death of MDA-MB-231 cells and this death was suppressed by Fer-1, Deferoxamine, and vitamin E^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Eleostearic acid (0.5% of total lipid given; p.o.) inhibits Sodium Arsenite-induced oxidative stress, including reversal of antioxidant enzyme activity and reduction of lipid peroxidation levels^[2].
Oral administration of tung oil, naturally rich inα-Eleostearic acid, to mice limits tumor growth and metastasis in an aggressive TNBC orthotopic xenograft model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

278.43

C₁₈H₃₀O₂

506-23-0

Liquid

Colorless to light yellow

CCCC/C=C/C=C/C=C\CCCCCCCC(O)=O

Shipping with dry ice.

-80°C, protect from light, stored under nitrogen

• [1]. Kobori M, et, al. Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd. J Agric Food Chem. 2008 Nov 26;56(22):10515-20.  [Content Brief]

  [2]. Saha SS, et, al. Comparative study of antioxidant activity of alpha-eleostearic acid and punicic acid against oxidative stress generated by sodium arsenite. Food Chem Toxicol. 2009 Oct;47(10):2551-6.  [Content Brief]

  [3]. Beatty A, et, al. Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1. Nat Commun. 2021 Apr 14;12(1):2244.  [Content Brief]