1-O-Tigloyl-1-O-debenzoylohchinal

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1-O-Tigloyl-1-O-debenzoylohchinal is an orally active limonoid-type triterpenoid anti-inflammatory and peripheral analgesic agent isolated from the fruits of Melia toosendan. 1-O-Tigloyl-1-O-debenzoylohchinal significantly inhibits acetic acid (HY-Y0319)-induced increase in vascular permeability, λ-Carrageenan (HY-N9470)-induced paw edema, and acetic acid-induced writhing response in mice. 1-O-Tigloyl-1-O-debenzoylohchinal shows no significant analgesic effect in the hot-plate test, and acts mainly on the peripheral rather than the central nervous system. 1-O-Tigloyl-1-O-debenzoylohchinal can be widely used in the research of acute or chronic inflammation, stomachache and other related diseases.

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1-O-Tigloyl-1-O-debenzoylohchinal 화학구조

CAS No. : 122688-84-0

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vivo

1-O-Tigloyl-1-O-debenzoylohchinal (compound 2) (100 mg/kg; p.o.; single administration) significantly inhibits acetic acid-induced vascular permeability in mice and suppresses acetic acid-induced writhing response in mice^[1].
1-O-Tigloyl-1-O-debenzoylohchinal (100 mg/kg; p.o.; single administration) significantly inhibits λ-carrageenan-induced hind paw edema in mice at 2 h and 4 h after carrageenan injection^[1].
1-O-Tigloyl-1-O-debenzoylohchinal (100 mg/kg; p.o.; single administration) exerts no significant effect on the hot-plate reaction latency in mice within 120 minutes after administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	ICR mice with Inflammation (male or female, 18-22g)^[1]
Dosage:	100 mg/kg
Administration:	p.o.; single dose
Result:	Produced a supernatant absorbance value of 0.031 ± 0.023, which represented a significant reduction in vascular permeability compared to the control group (p < 0.01).\nReduced hind paw swelling to 0.43 ± 0.09 mL at 2 hours (p < 0.01) and 0.96 ± 0.19 mL at 4 hours (p < 0.01) compared to the control group; no significant reduction was observed at 6 hours (1.22 ± 0.16 mL).

Animal Model:	ICR mice with Nociception (male or female, 18-22g)^[1]
Dosage:	100 mg/kg
Administration:	p.o.; single dose
Result:	Reduced the number of writhes to 12.4 ± 4.24, resulting in a 46.5% inhibitory ratio (p < 0.05) compared to the control group.\nProduced no significant changes in hot-plate latency at any time point post-administration, with latencies of 20.43 ± 6.09 s at 30 minutes, 20.83 ± 4.78 s at 60 minutes, and 21.22 ± 7.16 s at 120 minutes, which were comparable to baseline and control values.

분자량

566.68

화학식

C₃₃H₄₂O₈

CAS No.

122688-84-0

SMILES

C[C@@]12[C@@](O[C@@]3([H])C2=C([C@H](C4=COC=C4)C3)C)([H])[C@@]5([H])[C@]6([H])[C@@]([C@H]1CC=O)([C@H](C[C@H]([C@]6(CO5)C)OC(C)=O)OC(/C(C)=C/C)=O)C

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Xie F, et al. Anti-inflammatory and analgesic activities of ethanolic extract and two limonoids from Melia toosendan fruit. J Ethnopharmacol. 2008;117(3):463-466. [Content Brief]