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  4. 2-(Chloromethyl)pyridine hydrochloride

2-(Chloromethyl)pyridine hydrochloride  (Synonyms: Picolyl chloride hydrochloride)

Cat. No.: HY-W007502 Purity: 99.88%
COA
SDS
Handling Instructions Technical Support

2-(Chloromethyl)pyridine (Picolyl chloride) hydrochloride is an alkylating agent that can be used in organic synthesis reactions.

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2-(Chloromethyl)pyridine hydrochloride

2-(Chloromethyl)pyridine hydrochloride 화학구조

CAS No. : 6959-47-3

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
10 g 해외재고보유
25 g 해외재고보유
50 g 해외재고보유
100 g 해외재고보유
250 g 해외재고보유
> 100 g   견적 받기  

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2-(Chloromethyl)pyridine hydrochloride Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

2-(Chloromethyl)pyridine (Picolyl chloride) hydrochloride is an alkylating agent that can be used in organic synthesis reactions[1][2].

In Vitro

2-(Chloromethyl)pyridine hydrochloride can introduce pyridine groups in the reaction with calix[4]arenes, and the conformation of the product is affected by the base used[1].
2-(Chloromethyl)pyridine hydrochloride is an electrophile used in the alkylation reaction of p-tert-butylcalix[5]arene, which can generate a variety of pyridinyl homologues[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-(Chloromethyl)pyridine hydrochloride Related Antibodies
분자량

164.03

화학식

C6H7Cl2N
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

ClCC1=CC=CC=N1.Cl
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 50 mg/mL (304.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0964 mL 30.4822 mL 60.9645 mL
5 mM 1.2193 mL 6.0964 mL 12.1929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (15.24 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (15.24 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서

Purity: 99.88%

SDS (614 KB)

COA (251 KB) HNMR (115 KB) RP-HPLC (242 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.0964 mL 30.4822 mL 60.9645 mL 152.4111 mL
5 mM 1.2193 mL 6.0964 mL 12.1929 mL 30.4822 mL
10 mM 0.6096 mL 3.0482 mL 6.0964 mL 15.2411 mL
15 mM 0.4064 mL 2.0321 mL 4.0643 mL 10.1607 mL
20 mM 0.3048 mL 1.5241 mL 3.0482 mL 7.6206 mL
25 mM 0.2439 mL 1.2193 mL 2.4386 mL 6.0964 mL
30 mM 0.2032 mL 1.0161 mL 2.0321 mL 5.0804 mL
40 mM 0.1524 mL 0.7621 mL 1.5241 mL 3.8103 mL
50 mM 0.1219 mL 0.6096 mL 1.2193 mL 3.0482 mL
60 mM 0.1016 mL 0.5080 mL 1.0161 mL 2.5402 mL
80 mM 0.0762 mL 0.3810 mL 0.7621 mL 1.9051 mL
100 mM 0.0610 mL 0.3048 mL 0.6096 mL 1.5241 mL
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2-(Chloromethyl)pyridine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-(Chloromethyl)pyridine6959-47-3Picolyl chlorideBiochemical Assay ReagentsDrug IntermediateDrug Iintermediatebiochemical reagentbiological materialorganic compoundlife sciencealkylating agentInhibitorinhibitorinhibit

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상품명:
2-(Chloromethyl)pyridine hydrochloride
Cat. No.:
HY-W007502
수량:
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