2-Desoxy-4-epi-pulchellin

製品番号: HY-N1725 純度: 99.97%: Data Sheet SDS COA 取扱説明書
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2-Desoxy-4-epi-pulchellin (compound 13) is a compound isolated from dichloromethane-soluble portion of Polygonum hydropiper.

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2-Desoxy-4-epi-pulchellin 構造式

CAS 番号 : 122872-03-1

容量	価格（税別）	在庫状況	数量
1 mg	$75	在庫あり	Estimated Time of Arrival: December 31
5 mg	$180	在庫あり	Estimated Time of Arrival: December 31
10 mg		お問い合わせ
50 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

2-Desoxy-4-epi-pulchellin (compound 13) is a compound isolated from dichloromethane-soluble portion of Polygonum hydropiper^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.2 3 Compound: 4	Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
A549	IC₅₀	6.2 3 Compound: 4	Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
A549	IC₅₀	6.2 3 Compound: 4	Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay Cytotoxicity against human A549 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
DU-145	IC₅₀	3.1 3 Compound: 4	Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
DU-145	IC₅₀	3.1 3 Compound: 4	Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
DU-145	IC₅₀	3.1 3 Compound: 4	Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay Cytotoxicity against human DU145 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HCT-116	IC₅₀	4.43 3 Compound: 1; PCL	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30711391]
HCT-116	IC₅₀	4.43 3 Compound: 1; PCL	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30711391]
HCT-116	IC₅₀	4.43 3 Compound: 1; PCL	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30711391]
HL-60	IC₅₀	2.4 3 Compound: 4	Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HeLa	IC₅₀	6 3 Compound: 4	Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HeLa	IC₅₀	6 3 Compound: 4	Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HL-60	IC₅₀	2.4 3 Compound: 4	Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HT-29	IC₅₀	3.37 3 Compound: 1; PCL	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30711391]
HL-60	IC₅₀	2.4 3 Compound: 4	Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay Cytotoxicity against human HL60 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HeLa	IC₅₀	6 3 Compound: 4	Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay Cytotoxicity against human HeLa cells after 72 hrs by CCK8 assay	[PMID: 26316467]
HT-29	IC₅₀	3.37 3 Compound: 1; PCL	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30711391]
HT-29	IC₅₀	3.37 3 Compound: 1; PCL	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30711391]
K562	IC₅₀	17 3 Compound: 4	Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
K562	IC₅₀	17 3 Compound: 4	Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
MCF7	IC₅₀	9.8 6 Compound: 9, pseudoguaianolide	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21109433]
K562	IC₅₀	17 3 Compound: 4	Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay Cytotoxicity against human K562 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
MCF7	IC₅₀	11 3 Compound: 4	Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
MCF7	IC₅₀	9.8 6 Compound: 9, pseudoguaianolide	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21109433]
MCF7	IC₅₀	11 3 Compound: 4	Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
MCF7	IC₅₀	11 3 Compound: 4	Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay Cytotoxicity against human MCF7 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
MDCK	IC₅₀	29.3 3 Compound: 4	Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining	[PMID: 26316467]
MDCK	IC₅₀	29.3 3 Compound: 4	Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining	[PMID: 26316467]
MCF7	IC₅₀	9.8 6 Compound: 9, pseudoguaianolide	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 21109433]
MDCK	IC₅₀	47.3 3 Compound: 4	Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining	[PMID: 26316467]
MDCK	IC₅₀	47.3 3 Compound: 4	Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining	[PMID: 26316467]
MDCK	IC₅₀	29.3 3 Compound: 4	Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining	[PMID: 26316467]
MOLT-4	IC₅₀	5.5 3 Compound: 4	Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
MDCK	IC₅₀	47.3 3 Compound: 4	Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as protection against virus-induced cytopathic effect after 48 hrs by crystal violet staining	[PMID: 26316467]
MOLT-4	IC₅₀	5.5 3 Compound: 4	Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
NCI-H1975	IC₅₀	13 3 Compound: 4	Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
MOLT-4	IC₅₀	5.5 3 Compound: 4	Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay Cytotoxicity against human MOLT4 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
NCI-H1975	IC₅₀	13 3 Compound: 4	Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
Neutrophil	IC₅₀	> 10 6 Compound: 5	Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry	[PMID: 24997688]
Neutrophil	IC₅₀	>10 6 Compound: 5	Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry	[PMID: 24997688]
NCI-H1975	IC₅₀	13 3 Compound: 4	Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay Cytotoxicity against human NCI-H1975 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
RAW264.7	IC₅₀	9.89 3 Compound: 19	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method	[PMID: 21924800]
Neutrophil	IC₅₀	> 10 6 Compound: 5	Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry Inhibition of FMLP/CB-induced elastase release in human neutrophils after 5 mins by spectrophotometry	[PMID: 24997688]
Neutrophil	IC₅₀	> 10 6 Compound: 5	Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils by ferricytochrome c reduction method Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils by ferricytochrome c reduction method	[PMID: 24997688]
RAW264.7	IC₅₀	0.1 3 Compound: 14	Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs	[PMID: 20515062]
RAW264.7	IC₅₀	2.5 3 Compound: 15	Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay	[PMID: 27276091]
Neutrophil	IC₅₀	> 10 6 Compound: 5	Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils by ferricytochrome c reduction method Inhibition of FMLP/CB-induced superoxide anion generation in human neutrophils by ferricytochrome c reduction method	[PMID: 24997688]
RAW264.7	IC₅₀	0.1 3 Compound: 14	Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs	[PMID: 20515062]
RAW264.7	IC₅₀	14.9 3 Compound: 5	Inhibition of NO production in LPS/IFN-gamma activated mouse RAW264.7 cells after 24 hrs by Griess assay Inhibition of NO production in LPS/IFN-gamma activated mouse RAW264.7 cells after 24 hrs by Griess assay	[PMID: 24997688]
RAW264.7	IC₅₀	2.5 3 Compound: 15	Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay	[PMID: 27276091]
RAW264.7	IC₅₀	14.9 3 Compound: 5	Inhibition of NO production in LPS/IFN-gamma activated mouse RAW264.7 cells after 24 hrs by Griess assay Inhibition of NO production in LPS/IFN-gamma activated mouse RAW264.7 cells after 24 hrs by Griess assay	[PMID: 24997688]
RAW264.7	IC₅₀	9.89 3 Compound: 19	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method	[PMID: 21924800]
SGC-7901	IC₅₀	22 3 Compound: 4	Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
RAW264.7	IC₅₀	0.1 3 Compound: 14	Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs	[PMID: 20515062]
U-937	IC₅₀	2.2 3 Compound: 4	Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
SGC-7901	IC₅₀	22 3 Compound: 4	Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
RAW264.7	IC₅₀	14.9 3 Compound: 5	Inhibition of NO production in LPS/IFN-gamma activated mouse RAW264.7 cells after 24 hrs by Griess assay Inhibition of NO production in LPS/IFN-gamma activated mouse RAW264.7 cells after 24 hrs by Griess assay	[PMID: 24997688]
RAW264.7	IC₅₀	2.5 3 Compound: 15	Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay	[PMID: 27276091]
U-937	IC₅₀	2.2 3 Compound: 4	Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
RAW264.7	IC₅₀	9.89 3 Compound: 19	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method	[PMID: 21924800]
SGC-7901	IC₅₀	22 3 Compound: 4	Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay Cytotoxicity against human SGC7901 cells after 72 hrs by CCK8 assay	[PMID: 26316467]
U-937	IC₅₀	2.2 3 Compound: 4	Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay Cytotoxicity against human U937 cells after 72 hrs by CCK8 assay	[PMID: 26316467]

分子量

250.33

分子式

C₁₅H₂₂O₃

CAS 番号

122872-03-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(O[C@]1([H])[C@]2([H])C[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@H](C)C1)C2=C

Structure Classification

Others

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (99.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9947 mL	19.9736 mL	39.9473 mL
5 mM	0.7989 mL	3.9947 mL	7.9895 mL
10 mM	0.3995 mL	1.9974 mL	3.9947 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.97%

Select Batch:

データシート (274 KB) SDS (252 KB)

COA (257 KB) HNMR (200 KB) LCMS (89 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Xiao H, et al. Biological evaluation of phytoconstituents from Polygonum hydropiper. Nat Prod Res. 2017;31(17):2053-2057. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9947 mL	19.9736 mL	39.9473 mL	99.8682 mL
	5 mM	0.7989 mL	3.9947 mL	7.9895 mL	19.9736 mL
	10 mM	0.3995 mL	1.9974 mL	3.9947 mL	9.9868 mL
	15 mM	0.2663 mL	1.3316 mL	2.6632 mL	6.6579 mL
	20 mM	0.1997 mL	0.9987 mL	1.9974 mL	4.9934 mL
	25 mM	0.1598 mL	0.7989 mL	1.5979 mL	3.9947 mL
	30 mM	0.1332 mL	0.6658 mL	1.3316 mL	3.3289 mL
	40 mM	0.0999 mL	0.4993 mL	0.9987 mL	2.4967 mL
	50 mM	0.0799 mL	0.3995 mL	0.7989 mL	1.9974 mL
	60 mM	0.0666 mL	0.3329 mL	0.6658 mL	1.6645 mL
	80 mM	0.0499 mL	0.2497 mL	0.4993 mL	1.2484 mL