2-Furoyl-LIGRLO-amide TFA
Based on 3 publication(s) in Google Scholar
2-Furoyl-LIGRLO-amide TFA is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0..
For research use only. We do not sell to patients.
- CAS No.: 2468029-34-5
- Formula: C38H64F3N11O10
- Molecular Weight:891.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-P0078
TRAP-6
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HY-P1308
SLIGRL-NH2
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HY-P0283
Protease-Activated Receptor-2, amide
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HY-P1314
2-Furoyl-LIGRLO-amide
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HY-P1309A
PAR-4 Agonist Peptide, amide TFA
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HY-P0226A
TFLLR-NH2TFA
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HY-P0297
Protease-Activated Receptor-4
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HY-P1263A
tcY-NH2 TFA
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HY-P1312
LRGILS-NH2
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HY-P1310
VKGILS-NH2
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HY-10119
Vorapaxar
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HY-P0226
TFLLR-NH2
Publications Citing Use of MedChemExpress (MCE) 2-Furoyl-LIGRLO-amide TFA
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Biological Activity
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PAR2 |
2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is equally effective to and 10 to 25 times more potent than SLIGRLNH2 for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively[1].
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is 10 to 300 times more potent than SLIGRL-NH2. Unlike trans-cinnamoyl-LIGRLO-NH2, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male (2/3-month-old) Trpv3-/- and WT mice[2]
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Dosage:10 μg
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Administration:Injected intradermally at the nape of the neck
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Result:Was involved in PAR2- induced acute itch.
Chemical Information
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CAS No. 2468029-34-5
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Molecular Weight 891.98
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Formula C38H64F3N11O10
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Sequence
{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2
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Sequence Shortening
{Fur-2-oyl}-LIGRL-{Orn}-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Pharmacol Res
PAR2 deficiency impairs antitumor immunity and attenuates anti-PD1 efficacy in colorectal cancer. [Abstract]2025 May:215:107721. PMID: 40174816 -
J Immunother Cancer
Targeting PAR-2 with a negative allosteric modulator increases tumor antigen presentation and potentiates anti-PD-1 immunotherapy. [Abstract]2026 Apr 3;14(4):e013507. PMID: 41932811 -
PLoS Negl Trop Dis
A novel trypsin of Trichinella spiralis mediates larval invasion of gut epithelium via binding to PAR2 and activating ERK1/2 pathway. [Abstract]2024 Jan 2;18(1):e0011874. PMID: 38166153
Purity & Documentation
References
[1]. McGuire JJ, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther. 2004 Jun;309(3):1124-31. [Content Brief]
[2]. Lohman RJ, et al. An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 2012 Jul;26(7):2877-87. [Content Brief]
[3]. Jiahui Zhao, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Furoyl-LIGRLO-amide TFA Related Classifications
HY-P1314A Related Classifications
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