1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)
  3. 2-Furoyl-LIGRLO-amide TFA

2-Furoyl-LIGRLO-amide TFA 

Cat. No.: HY-P1314A
Handling Instructions

2-Furoyl-LIGRLO-amide TFA is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0..

For research use only. We do not sell to patients.

Custom Peptide Synthesis

2-Furoyl-LIGRLO-amide TFA Chemical Structure

2-Furoyl-LIGRLO-amide TFA Chemical Structure

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Description

2-Furoyl-LIGRLO-amide TFA is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0[1][2]..

IC50 & Target

Proteinase-activated receptor 2 (PAR2)[1]

In Vitro

2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is equally effective to and 10 to 25 times more potent than SLIGRLNH2 for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively[1].
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is 10 to 300 times more potent than SLIGRL-NH2. Unlike trans-cinnamoyl-LIGRLO-NH2, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries[1].

Molecular Weight

891.98

Formula

C₃₈H₆₄F₃N₁₁O₁₀

Sequence

{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2

Sequence Shortening

{Fur-2-oyl}-LIGRL-{Orn}-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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KeyWords:

2-Furoyl-LIGRLO-amide | Protease-Activated Receptor (PAR) | Thrombin receptors | Inhibitor | inhibitor | inhibit

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Product name:
2-Furoyl-LIGRLO-amide TFA
Cat. No.:
HY-P1314A
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