2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. 2-Furoyl-LIGRLO-amide TFA

2-Furoyl-LIGRLO-amide TFA is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0..

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2-Furoyl-LIGRLO-amide TFA Chemical Structure

2-Furoyl-LIGRLO-amide TFA Chemical Structure

CAS No. : 2468029-34-5

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2-Furoyl-LIGRLO-amide TFA Related Antibodies

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Description

2-Furoyl-LIGRLO-amide TFA is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0[1][2]..

IC50 & Target

PAR2

 

In Vitro

2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is equally effective to and 10 to 25 times more potent than SLIGRLNH2 for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively[1].
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is 10 to 300 times more potent than SLIGRL-NH2. Unlike trans-cinnamoyl-LIGRLO-NH2, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Furoyl-LIGRLO-amide TFA Related Antibodies
In Vivo

Furoyl-LIGRLO-amide TFA (injected intradermally at the nape of the neck; 10 μg; pre-injected) exhibits fewer scratches in response to 2-Furoyl-LIGRLO-amide but not to histamine in Trpv3-/- mice. But it decreases significantly the number of scratches in WT mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male (2/3-month-old) Trpv3-/- and WT mice[2]
Dosage: 10 μg
Administration: Injected intradermally at the nape of the neck
Result: Was involved in PAR2- induced acute itch.
Molecular Weight

891.98

Formula

C38H64F3N11O10
CAS No.
Sequence

{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2
Sequence Shortening

{Fur-2-oyl}-LIGRL-{Orn}-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2-Furoyl-LIGRLO-amide TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Furoyl-LIGRLO-amide2468029-34-5Protease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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