1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)
  3. 2-Furoyl-LIGRLO-amide

2-Furoyl-LIGRLO-amide 

Cat. No.: HY-P1314
Handling Instructions

2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0..

For research use only. We do not sell to patients.

Custom Peptide Synthesis

2-Furoyl-LIGRLO-amide Chemical Structure

2-Furoyl-LIGRLO-amide Chemical Structure

CAS No. : 729589-58-6

Size Stock
1 mg   Get quote  
5 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of 2-Furoyl-LIGRLO-amide:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0[1][2]..

IC50 & Target

Proteinase-activated receptor 2 (PAR2)[1]

In Vitro

2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is equally effective to and 10 to 25 times more potent than SLIGRLNH2 for increasing intracellular calcium in cultured human and rat PAR2-expressing cells, respectively[1].
In bioassays of tissue PAR2 activity, measured as arterial vasodilation and hyperpolarization, 2-Furoyl-LIGRLO-amide (2-Furoyl-LIGRLO-NH2) is 10 to 300 times more potent than SLIGRL-NH2. Unlike trans-cinnamoyl-LIGRLO-NH2, 2-Furoyl-LIGRLO-amide do not cause a prominent non-PAR2-mediated contraction of murine femoral arteries[1].

Molecular Weight

777.95

Formula

C₃₆H₆₃N₁₁O₈

CAS No.

729589-58-6

Sequence

{Fur-2-oyl}-Leu-Ile-Gly-Arg-Leu-{Orn}-NH2

Sequence Shortening

{Fur-2-oyl}-LIGRL-{Orn}-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

2-Furoyl-LIGRLO-amideProtease-Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
2-Furoyl-LIGRLO-amide
Cat. No.:
HY-P1314
Quantity:
MCE Japan Authorized Agent: