3′-Phosphoadenosine 5′-phosphosulfate tetralithium salt  (Synonyms: PAPS tetralithium salt)

3′-Phosphoadenosine 5′-phosphosulfate tetralithium salt (PAPS tetralithium salt) is the cosubstrate and the source of sulfonic acid groups in sulfation reactions. 3′-Phosphoadenosine 5′-phosphosulfate tetralithium salt is important for maintaining sulfation balance in living organisms^[1].

3'-Phosphoadenosine 5'-phosphosulfate tetralithium salt is the sulfuric acid group donor in the sulfation reaction. Its availability, rather than the activity of the sulfation enzyme itself, is the main limiting factor for the capacity of sulfation reactions in the body^[1][3].
3′-phosphoadenosine 5′-phosphosulfate tetralithium salt is involved in the transport of membrane vesicles through active transport: it is accomplished by relying on specific PAPS transport proteins (PAPST)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

531.00

C₁₀H₁₁Li₄N₅O₁₃P₂S

102029-54-9

Solid

White to off-white

O=P(O[Li])(O[Li])O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C32)O[C@@H]1COP(OS(=O)(O[Li])=O)(O[Li])=O

Shipping with dry ice.

-80°C

• [1]. Klaassen CD, et al., Sulfation and sulfotransferases 5: the importance of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) in the regulation of sulfation. FASEB J. 1997 May;11(6):404-18.  [Content Brief]

  [2]. Nishihara S. Assay of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) transport activity. 2021 Aug 11 [updated 2022 Apr 30]. In: Nishihara S, Angata K, Aoki-Kinoshita KF, Hirabayashi J, editors. Glycoscience Protocols (GlycoPODv2) [Internet]. Saitama (JP): Japan Consortium for Glycobiology and Glycotechnology; 2021–.  [Content Brief]

  [3]. Vargas F, et al. 3'-Phosphoadenosine 5'-phosphosulfate biosynthesis and the sulfation of cholecystokinin by the tyrosylprotein-sulfotransferase in rat brain tissue. Chem Biol Interact. 1994 Jun;92(1-3):281-91.  [Content Brief]