2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 

製品番号: HY-152819
取扱説明書 Technical Support

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

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4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 構造式

CAS 番号 : 847551-49-9

容量 在庫状況
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4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 関連抗体

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製品説明

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
4.38 μM
Compound: 6
Cytotoxicity against human CCRF-CEM cells incubated for 3 days by XTT assay
Cytotoxicity against human CCRF-CEM cells incubated for 3 days by XTT assay
[PMID: 22877872]
DU-145 GI50
3.38 μM
Compound: 6
Cytostatic activity against human DU145 cells incubated for 3 days by SRB assay
Cytostatic activity against human DU145 cells incubated for 3 days by SRB assay
[PMID: 22877872]
HCT-116 GI50
6.65 μM
Compound: 6
Cytostatic activity against human HCT116 cells incubated for 3 days by SRB assay
Cytostatic activity against human HCT116 cells incubated for 3 days by SRB assay
[PMID: 22877872]
HL-60 IC50
> 10 μM
Compound: 6
Cytotoxicity against human HL60 cells incubated for 3 days by XTT assay
Cytotoxicity against human HL60 cells incubated for 3 days by XTT assay
[PMID: 22877872]
HeLa S3 IC50
7.5 μM
Compound: 6
Cytotoxicity against human HeLaS3 cells incubated for 3 days by XTT assay
Cytotoxicity against human HeLaS3 cells incubated for 3 days by XTT assay
[PMID: 22877872]
Huh-7 CC50
19.75 μM
Compound: 6
Toxicity against human HuH7 cells incubated for 3 days by CellTiter 96 AQueous One Solution cell proliferation assay
Toxicity against human HuH7 cells incubated for 3 days by CellTiter 96 AQueous One Solution cell proliferation assay
[PMID: 22877872]
Huh-7 EC50
0.37 μM
Compound: 6
Antiviral activity against Hepatitis C virus subtype 1a replicons infected in human HuH7 cells assessed as reduction in viral RNA levels by Rt-PCR
Antiviral activity against Hepatitis C virus subtype 1a replicons infected in human HuH7 cells assessed as reduction in viral RNA levels by Rt-PCR
[PMID: 22877872]
Huh-7 EC50
0.38 μM
Compound: 6
Antiviral activity against Hepatitis C virus subtype 1b replicons infected in human HuH7 cells assessed as reduction in viral RNA levels by Rt-PCR
Antiviral activity against Hepatitis C virus subtype 1b replicons infected in human HuH7 cells assessed as reduction in viral RNA levels by Rt-PCR
[PMID: 22877872]
NCI-H23 GI50
0.79 μM
Compound: 6
Cytostatic activity against human NCI-H23 cells incubated for 3 days by SRB assay
Cytostatic activity against human NCI-H23 cells incubated for 3 days by SRB assay
[PMID: 22877872]
分子量

406.18

分子式

C12H15IN4O4
CAS 番号
SMILES

OC[C@@H]1[C@@H](O)[C@](O)(C)[C@H](N2C=C(I)C3=C2N=CN=C3N)O1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine Related Classifications

  • Molarity Calculator

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine847551-49-9Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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製品名:
4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
製品番号:
HY-152819
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