1. GPCR/G Protein
  2. LPL Receptor
  3. 4-Deoxypyridoxine 5'-phosphate

4-Deoxypyridoxine 5'-phosphate 

Cat. No.: HY-N2553 Purity: ≥98.0%
Handling Instructions

4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase.

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4-Deoxypyridoxine 5'-phosphate Chemical Structure

4-Deoxypyridoxine 5'-phosphate Chemical Structure

CAS No. : 883-84-1

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10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
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10 mg USD 200 In-stock
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50 mg USD 500 In-stock
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100 mg USD 850 In-stock
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Description

4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase[1][2][3].

IC50 & Target

Sphingosine 1-phosphate (S1P)[1]
Ornithine decarboxylase[2]
Glutamate apodecarboxylase[3]

Molecular Weight

233.16

Formula

C₈H₁₂NO₅P

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (428.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2889 mL 21.4445 mL 42.8890 mL
5 mM 0.8578 mL 4.2889 mL 8.5778 mL
10 mM 0.4289 mL 2.1445 mL 4.2889 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.72 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.72 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
4-Deoxypyridoxine 5'-phosphate
Cat. No.:
HY-N2553
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