4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium

Name: 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium
Brand: MedChemExpress
SKU: HY-D1633A
Rating: 4.5 (1 reviews)

Cat. No.: HY-D1633A Purity: 99.92%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium is a fluorescent dye. 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium undergoes desulphation by galactose-6-sulphate sulphatase to form 4-methylumbelliferyl-β-D-galactopyranoside, which is cleaved by β-galactosidase to release fluorescent 4-methylumbelliferone. 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium interacts with N-acetylgalactosamine-6-sulfate sulfatase (GALNS) via hydrogen bonds, electrostatic interactions, and steric interactions. 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium serves as a substrate in assays measuring galactose-6-sulphate sulphatase and GALNS activity. 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium can be used for the research of Morquio disease type A (mucopolysaccharidosis IV A).

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4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium 화학구조

CAS No. : 206443-06-3

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	견적 받기
10 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium:

4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate 견적 받기

1 Publications Citing Use of MCE 4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium

•QJM. 2025 Jan 1;118(1):17-23. [Abstract]

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium acts as a fluorogenic substrate for Gal-6S sulphatase, enabling sensitive detection of enzyme activity in normal human leucocytes and fibroblasts^[1].
4-Methylumbelliferyl-β-D-galactopyranoside 6-sulfate sodium binds to wild-type human N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme with an affinity energy of -121.685 kJ/mol, forming hydrogen, electrostatic, and steric interactions with specific active cavity residues^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

440.35

화학식

C₁₆H₁₇NaO₁₁S

CAS No.

206443-06-3

Appearance

Solid

Color

White to off-white

Emission (Em)

425

Excitation (Ex)

318

SMILES

CC(C1=CC=C(O[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2O)O)O)COS(=O)(O[Na])=O)C=C1O3)=CC3=O

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

DMSO : ≥ 30 mg/mL (68.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2709 mL	11.3546 mL	22.7092 mL
5 mM	0.4542 mL	2.2709 mL	4.5418 mL
10 mM	0.2271 mL	1.1355 mL	2.2709 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

순도&문서

Purity: 99.92%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. van Diggelen OP, et al. A fluorimetric enzyme assay for the diagnosis of Morquio disease type A (MPS IV A). Clin Chim Acta. 1990 Feb 28;187(2):131-9. [Content Brief]

[2]. Olarte-Avellaneda S, et al. Computational analysis of human N-acetylgalactosamine-6-sulfate sulfatase enzyme: an update in genotype-phenotype correlation for Morquio A. Mol Biol Rep. 2014 Nov;41(11):7073-88. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2709 mL	11.3546 mL	22.7092 mL	56.7730 mL
	5 mM	0.4542 mL	2.2709 mL	4.5418 mL	11.3546 mL
	10 mM	0.2271 mL	1.1355 mL	2.2709 mL	5.6773 mL
	15 mM	0.1514 mL	0.7570 mL	1.5139 mL	3.7849 mL
	20 mM	0.1135 mL	0.5677 mL	1.1355 mL	2.8387 mL
	25 mM	0.0908 mL	0.4542 mL	0.9084 mL	2.2709 mL
	30 mM	0.0757 mL	0.3785 mL	0.7570 mL	1.8924 mL
	40 mM	0.0568 mL	0.2839 mL	0.5677 mL	1.4193 mL
	50 mM	0.0454 mL	0.2271 mL	0.4542 mL	1.1355 mL
	60 mM	0.0378 mL	0.1892 mL	0.3785 mL	0.9462 mL