5'-ODMT cEt G Phosphoramidite (Amidite)

Cat. No.: HY-148504 Pureza: 99.43%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

5'-ODMT cEt G Phosphoramidite (Amidite) Estructura química

No. CAS : 945628-66-0

Tamaño	Stock	Cantidad
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
500 mg	Obtener un presupuesto
1 g	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity^[1]^[2].

In Vitro

5'-ODMT cEt G Phosphoramidite Amidite enhances the RNA-binding ability, affects the construction of antisense oligonucleotides (ASOs) and reduces the toxicity of ASOs through alternation of nucleotides conformation and 5'-alkyl DNA modification^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

881.95

Fòrmula

C₄₆H₅₆N₇O₉P

No. CAS

945628-66-0

Appearance

Solid

Color

White to off-white

SMILES

CC(C)N(C(C)C)P(OCCC#N)O[C@@H]([C@](O[C@H]1C)([H])[C@H](N2C3=C(C(N=C(N3)NC(C(C)C)=O)=O)N=C2)O4)[C@@]41COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (113.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1339 mL	5.6693 mL	11.3385 mL
5 mM	0.2268 mL	1.1339 mL	2.2677 mL
10 mM	0.1134 mL	0.5669 mL	1.1339 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.43%

Select Batch:

Ficha de datos (279 KB) SDS (252 KB)

COA (260 KB) HNMR (323 KB) RP-HPLC (227 KB) MS (69 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Vasquez G, et al. Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. [Content Brief]

[2]. Seth PP, et al. Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues. J Org Chem. 2010 Mar 5;75(5):1569-81. [Content Brief]

[3]. Vasquez G, et al., Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs. Nucleic Acids Res. 2021 Feb 26;49(4):1828-1839. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1339 mL	5.6693 mL	11.3385 mL	28.3463 mL
	5 mM	0.2268 mL	1.1339 mL	2.2677 mL	5.6693 mL
	10 mM	0.1134 mL	0.5669 mL	1.1339 mL	2.8346 mL
	15 mM	0.0756 mL	0.3780 mL	0.7559 mL	1.8898 mL
	20 mM	0.0567 mL	0.2835 mL	0.5669 mL	1.4173 mL
	25 mM	0.0454 mL	0.2268 mL	0.4535 mL	1.1339 mL
	30 mM	0.0378 mL	0.1890 mL	0.3780 mL	0.9449 mL
	40 mM	0.0283 mL	0.1417 mL	0.2835 mL	0.7087 mL
	50 mM	0.0227 mL	0.1134 mL	0.2268 mL	0.5669 mL
	60 mM	0.0189 mL	0.0945 mL	0.1890 mL	0.4724 mL
	80 mM	0.0142 mL	0.0709 mL	0.1417 mL	0.3543 mL
	100 mM	0.0113 mL	0.0567 mL	0.1134 mL	0.2835 mL