2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS)
  4. 6PPD

6PPD is a rubber antioxidant that scavenges ozone and forms nitro radicals. Exposure to 6PPD reduces the hatching rate, impairs spontaneous locomotor activity, shortens body length and causes malformations in zebrafish embryos. 6PPD also induces oxidative stress in zebrafish embryos.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

6PPD

6PPD 構造式

CAS 番号 : 793-24-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
10 g $25 在庫あり
25 g $48 在庫あり
50 g $68 在庫あり
100 g $95 在庫あり
250 g $200 在庫あり
500 g $300 在庫あり
1 kg $450 在庫あり

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of 6PPD:

6PPD 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

6PPD is a rubber antioxidant that scavenges ozone and forms nitro radicals. Exposure to 6PPD reduces the hatching rate, impairs spontaneous locomotor activity, shortens body length and causes malformations in zebrafish embryos. 6PPD also induces oxidative stress in zebrafish embryos[1].

体内実験

6PPD (0.0022-5 mg/L; aqueous exposure; daily renewal; 96-120 hours) causes concentration-dependent developmental toxicity, GH/IGF and HPT axis disruption, and oxidative stress in Danio rerio embryos/larvae, with a 96 h LC50 of 2.2 mg/L and significant developmental impairment and endocrine disruption observed at doses as low as 0.0022 mg/L[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: wild-type AB strain (2 hours post-fertilization embryos)[1]
Dosage: 0.0022 mg/L; 0.022 mg/L; 0.22 mg/L; 0.3125 mg/L; 0.625 mg/L; 1.25 mg/L; 2.5 mg/L; 5 mg/L
Administration: aqueous exposure; daily renewal; 96 hours (0.3125-5 mg/L); 120 hours (0.0022-0.22 mg/L)
Result: Determined the 96 h LC50 of 6PPD for zebrafish embryos as 2.2 mg/L .
Reduced hatchability by 25.6% (0.022 mg/L) and 78.9% (0.22 mg/L) relative to controls.
Reduced autonomous movement (60-second count at 96 hours) by 19.9% (0.022 mg/L) and 56.25% (0.22 mg/L) relative to controls.
分子量

268.40

分子式

C18H24N2
CAS 番号
Appearance

Solid

Color

Brown to gray

SMILES

CC(C)CC(NC1=CC=C(NC2=CC=CC=C2)C=C1)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 200 mg/mL (745.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7258 mL 18.6289 mL 37.2578 mL
5 mM 0.7452 mL 3.7258 mL 7.4516 mL
10 mM 0.3726 mL 1.8629 mL 3.7258 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 98.46%

COA (243 KB) HNMR (122 KB) RP-HPLC (102 KB) MS (120 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7258 mL 18.6289 mL 37.2578 mL 93.1446 mL
5 mM 0.7452 mL 3.7258 mL 7.4516 mL 18.6289 mL
10 mM 0.3726 mL 1.8629 mL 3.7258 mL 9.3145 mL
15 mM 0.2484 mL 1.2419 mL 2.4839 mL 6.2096 mL
20 mM 0.1863 mL 0.9314 mL 1.8629 mL 4.6572 mL
25 mM 0.1490 mL 0.7452 mL 1.4903 mL 3.7258 mL
30 mM 0.1242 mL 0.6210 mL 1.2419 mL 3.1048 mL
40 mM 0.0931 mL 0.4657 mL 0.9314 mL 2.3286 mL
50 mM 0.0745 mL 0.3726 mL 0.7452 mL 1.8629 mL
60 mM 0.0621 mL 0.3105 mL 0.6210 mL 1.5524 mL
80 mM 0.0466 mL 0.2329 mL 0.4657 mL 1.1643 mL
100 mM 0.0373 mL 0.1863 mL 0.3726 mL 0.9314 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

6PPD Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6PPD793-24-8Reactive Oxygen Species (ROS)zebrafish embryosoxidative stressgrowth hormone/insulin-like growth factor axisdevelopmental toxicityGH/IGF- and HPT axis-related genesendocrine disruptorzebrafish larvaehypothalamic-pituitary-thyroid axisInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
6PPD
製品番号:
HY-W011689
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.