8-Hydroxyguanine hydrochloride  (Synonyms: 8-Oxoguanine hydrochloride; 8-oxo-Gua hydrochloride)

8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage^[1][2].

The most common product of ROS-induced base damage is 8-Hydroxyguanine. Failure to promptly remove 8-Hydroxyguanine often causes mutations during DNA replication. 8-Hydroxyguanine is cleared from cells by the 8-oxoG DNA glycosylase 1 (OGG1)-mediated oxidative damage base excision repair pathway so as to prevent cells from suffering dysfunction due to oxidative stress^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

203.59

C₅H₆ClN₅O₂

1246818-54-1

O=C1NC(NC(N)=N2)=C(N1)C2=O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374(2):233-6.  [Content Brief]

  [2]. Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel). 2023 Jun 19;12(6):1300.  [Content Brief]