(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol 

(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a diterpene found in Abies georgei. (8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol is a nuclear factor kappa B (NF-κB) inhibitor that inhibits TNFα-triggered NF-κB activity (IC₅₀ = 8.7 μg/mL). (8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol exhibits anti-inflammatory activity and can inhibit NO production. (8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol shows significant cytotoxicity against tumor cells^[1].

(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol (Compound 54) inhibits LPS (HY-D1056)-induced NO production in RAW264.7 macrophages with an IC₅₀ of 21.6 μg/mL^[1].
(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol inhibits TNFα-triggered NF-κB activity in pNF-κB-luc-293 cells with an IC₅₀ of 8.7 μg/mL^[1].
(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol inhibits proliferation of LOVO human tumor cells with an IC₅₀ of 23.1 μg/mL^[1].
(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol inhibits proliferation of QGY-7703 human tumor cells with an IC₅₀ of 15.7 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

306.48

C₂₀H₃₄O₂

56682-25-8

C[C@@]12[C@]3([H])[C@](O[C@@](C3)([H])[C@](C)(O)C=C)(CC[C@@]1([H])C(C)(CCC2)C)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yang XW, et al. Isolation, structure, and bioactivities of abiesadines A-Y, 25 new diterpenes from Abies georgei Orr. Bioorg Med Chem. 2010;18(2):744-754.  [Content Brief]