2. GPCR/G Protein
  3. Amylin Receptor
  4. Amylin, amide, human

Amylin, amide, human  (Synonyms: アミリン (ヒト); DAP amide, human)

製品番号: HY-P1070 純度: 98.33%
COA 取扱説明書 Technical Support

Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent.

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Amylin, amide, human

Amylin, amide, human 構造式

CAS 番号 : 122384-88-7

容量 価格（税別） 在庫状況 数量
500 μg $200 在庫あり
1 mg $320 在庫あり
5 mg $990 在庫あり
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Amylin, amide, human 関連抗体

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製品説明

Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent[1].

体外実験

MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC50 of 35.2±7.5 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amylin, amide, human 関連抗体

Cell Viability Assay[1]

Cell Line: MCF-7 cells
Concentration: 0.001 nM, 0.01 nM, 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10μM, 100 μM, 1000 μM
Incubation Time:
Result: Resulted in the production of cAMP with an EC50 of 35.2±7.5 nM.
体内実験

Amylin, amide, human (400 μg peptide /kg body weight) is injected by subcutaneous route in separated groups of swiss male mice. A typical PK curve for the free amylin is observed, with a half-time of 23 min[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss male mice (8 weeks old)[1]
Dosage: 400 μg peptide /kg body weight (Pharmacokinetic Analysis)
Administration: Subcutaneous route; 24 hours
Result: Half-time of 23 min.
分子量

3903.28

分子式

C165H261N51O55S2
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bridge: Cys2-Cys7)
Sequence Shortening

KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2 (Disulfide bridge: Cys2-Cys7)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 1.67 mg/mL (0.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

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一般には略語で表示されます：C1V1 = C2V2

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Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 98.33%

COA (270 KB) RP-HPLC (258 KB) MS (224 KB)

取扱説明書 (2659 KB)
参考文献
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Amylin, amide, human Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amylin, amide, human122384-88-7DAP amide, humanAmylin ReceptorAMYRGlucoregulatoryHormonepancreaticmetabolismglucosehomeostasisglucagonsecretiongastricemptyingsatietyInhibitorinhibitorinhibit

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製品名:
Amylin, amide, human
製品番号:
HY-P1070
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