1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)

BAY 73-6691 (Synonyms: (R)-BAY 73-6691)

Cat. No.: HY-104028
Handling Instructions

BAY 73-6691 is a potent, selective brain penetrant PDE9A inhibitor.

For research use only. We do not sell to patients.

BAY 73-6691 Chemical Structure

BAY 73-6691 Chemical Structure

CAS No. : 794568-92-6

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5 mg USD 180 Get quote
10 mg USD 300 Get quote
25 mg USD 636 Get quote
50 mg USD 1092 Get quote
100 mg USD 1800 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


BAY 73-6691 is a potent, selective brain penetrant PDE9A inhibitor.

IC50 & Target


In Vitro

The BAY 73-6691 dose-dependently alleviates cell viability loss due to Aβ25-35 treatment. It is found that when SH-SY5Y cells are cultured by Aβ25-35, a high degree of cell apoptosis is observed, while additional stimulation with BAY 73-6691 causes attenuation of cell apoptosis. BAY 73-6691 dose-dependently attenuates oxidative stress induced by Aβ25-35, and BAY 73-6691 at 200 μg/mL almost neutralizes Aβ25-35-induced oxidative damage. The BAY 73-6691 attenuates Aβ25-35-induced increase of apoptosis cells[1].

In Vivo

BAY 73-6691 dose-dependently improves the acquisition performance in the Aβ25-35-injected mice on days 7 to 10 (day 7, F(5,54)=65.153; day 8, F(5,54)=62.340; day 9, F(5,54)=37.529; day 10, F(5,54)=38.624; P<0.001). BAY 73-6691 at 3 mg/kg can almost completely abolish the prolongation of escape-latency on days 9 to 10. BAY 73-6691 dose-dependently elevates the Aβ25-35-induced decrease of the dwell time on the 10th day post Aβ25-35 injection (day 10, F(5,54)=27.360, P<0.001). Results reveal that the Aβ25-35 injection and BAY 73-6691 treatment cause no influence on the swimming speed. Treatment with BAY 73-6691 does not cause detectable alteration of spatial memory in sham mice. BAY 73-6691 alleviates Aβ25-35-induced abnormalities of the above indices. The BAY 73-6691 causes no influence on the four indices mentioned above in sham mice. The BAY 73-6691 has no significant effect on the apoptosis of hippocampal neurons in sham mice[1].

Solvent & Solubility
In Vitro: 

DMSO : 160 mg/mL (448.52 mM; Need ultrasonic and warming)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8032 mL 14.0162 mL 28.0324 mL
5 mM 0.5606 mL 2.8032 mL 5.6065 mL
10 mM 0.2803 mL 1.4016 mL 2.8032 mL
*Please refer to the solubility information to select the appropriate solvent.
Cell Assay

The SH-SY5Y human neuroblastoma cell line is used in this study. The cells are routinely cultured in a mixture of Dulbecco's modified Eagle's medium (DMEM)/Ham's F12 containing 10% fetal bovine serum, 2 mM L-glutamine, antibiotic and antimycotic solution under a humidified atmosphere of 5% CO2-95% air at 37°C. The SH-SY5Y are plated in 96-well plates at 1×105 cells per well for the treatment with Aβ25-35 and the BAY 73-6691. Before experiments, freshly prepared Aβ25-35 peptide at 20 μM is added to the cells with or without exposure to different concentrations (50, 100, 150 and 200 μg/mL) of BAY 73-6691[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration

Male ICR mice (weighing 25 to 30 g) are used to induce the animal model of Alzheimer's disease (AD). All mice are housed in a temperature- and humidity-controlled room with a constant light-dark cycle (12 h/12 h) and are maintained on ad libitum food and water. BAY 73-6691 at different doses (0.3, 1 and 3 mg/kg) is consecutively injected (i.p.) once daily at 7:30 A.M on days 1 to 10 after injection of Aβ25-35 (day 0). Mice are divided into six groups: (I) sham, (II) Aβ, (III) Aβ+0.3 mg/kg BAY 73-6691, (IV) Aβ+1 mg/kg BAY 73-6691, (V) Aβ+3 mg/kg BAY 73-6691 and (VI) 3 mg/kg BAY 73-6691[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







O=C1C2=C(N(C3=CC=CC=C3Cl)N=C2)NC(C[[email protected]@H](C)C(F)(F)F)=N1


Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Product Name:
BAY 73-6691
Cat. No.:

BAY 73-6691

Cat. No.: HY-104028