1. MAPK/ERK Pathway
  2. JNK

BI-78D3 

Cat. No.: HY-10366 Purity: 99.69%
Data Sheet SDS Handling Instructions

BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor with IC50 of 280 nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.

For research use only. We do not sell to patients.
BI-78D3 Chemical Structure

BI-78D3 Chemical Structure

CAS No. : 883065-90-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $88 In-stock
5 mg $80 In-stock
10 mg $120 In-stock
25 mg $260 In-stock
50 mg $450 In-stock
100 mg $750 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor with IC50 of 280 nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. target: JNK IC 50: 280 nM 1) BI 78D3 Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC50= 500 nM) and prevents JNK substrate phosphorylation. 2) I-78D3 not only blocks JNK dependent Con A-induced liver damage but also restores insulin sensitivity in mouse models of type 2 diabetes. 3) The reference for animal administration is 25 mg/kg

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.6359 mL 13.1797 mL 26.3595 mL
5 mM 0.5272 mL 2.6359 mL 5.2719 mL
10 mM 0.2636 mL 1.3180 mL 2.6359 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

379.37

Formula

C₁₃H₉N₅O₅S₂

CAS No.

883065-90-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
BI-78D3
Cat. No.:
HY-10366
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