1. Cytoskeleton
  2. Myosin
  3. BTS

BTS (Synonyms: N-Benzyl-p-toluenesulfonamide; N-Tosylbenzylamine)

Cat. No.: HY-16690 Purity: 99.78%
Handling Instructions

BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC50s of ~5 µM for actin- and Ca2+-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers.

For research use only. We do not sell to patients.

BTS Chemical Structure

BTS Chemical Structure

CAS No. : 1576-37-0

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10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC50s of ~5 µM for actin- and Ca2+-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers[1][2].

IC50 & Target

IC50: ~5 µM (skeletal muscle myosin II S1 ATPase)

In Vitro

BTS (2-12 μM) inhibits the Ca2+-stimulated ATPase activity of myosin S1 in the absence of actin, with an IC50 of ~5 µM[1].
BTS (2-20 μM) reversibly inhibits the gliding motility rate of heavy meromyosin (HMM)[1].
BTS (100 μM) releases myosin from actin in the presence of ADP[1].
BTS (0-20 μM) reversibly inhibits isometric Ca2+-activated tension in skinned skeletal muscle fibres from rabbit and frog, with IC50s of ~3 µM and 1 µM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

261.34

Formula

C₁₄H₁₅NO₂S

CAS No.
SMILES

O=S(NCC1=CC=CC=C1)(C2=CC=C(C)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33.33 mg/mL (127.54 mM)

H2O : 0.1 mg/mL (0.38 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8264 mL 19.1322 mL 38.2643 mL
5 mM 0.7653 mL 3.8264 mL 7.6529 mL
10 mM 0.3826 mL 1.9132 mL 3.8264 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.57 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.57 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.78%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

BTSN-Benzyl-p-toluenesulfonamide N-TosylbenzylamineMyosinskeletalmusclemyosinIIsubfragmentS1ATPaseactinCa2+fibersInhibitorinhibitorinhibit

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BTS
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