1. Neuronal Signaling
    Membrane Transporter/Ion Channel
    Autophagy
  2. iGluR
    Autophagy

CX546 

Cat. No.: HY-12505 Purity: 99.50%
Data Sheet SDS Handling Instructions

CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.

For research use only. We do not sell to patients.
CX546 Chemical Structure

CX546 Chemical Structure

CAS No. : 215923-54-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 117 In-stock
10 mg USD 106 In-stock
50 mg USD 414 In-stock
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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. IC50 value: Target: AMPAR agonist in vitro: Treatments with the ampakine CX614 markedly and reversibly increased brain-derived neurotrophic factor (BDNF) mRNA and protein levels in cultured rat entorhinal/hippocampal slices [1]. in contrast to cyclothiazide or IDRA 21, the Ampakine CX546 binds specifically to the agonist bound nondesensitized receptor, most likely acting by destabilizing the desensitized receptor conformation [2]. In binding tests, CX546 caused an approximately 2-fold increase in the affinity for radiolabeled agonists, whereas CX516 was ineffective [3]. in vivo: Intraperitoneal injections of CX546 increased hippocampal BDNF mRNA levels in aged rats and middle-aged mice [1]. Administration of the positive modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPAR), CX546, during the conditioning phase only, improved the disrupted LI in mGluR5 knockout mice and facilitated LI in control C57BL/6J mice, given extended number of conditioning trails (four conditioning stimulus-unconditioned stimulus) [4].

References
Molecular Weight

247.29

Formula

C₁₄H₁₇NO₃

CAS No.

215923-54-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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CX546
Cat. No.:
HY-12505
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