1. Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. iGluR
  3. CX546


Cat. No.: HY-12505 Purity: 99.50%
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CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.

For research use only. We do not sell to patients.

CX546 Chemical Structure

CX546 Chemical Structure

CAS No. : 215923-54-9

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Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE CX546

    CX546 purchased from MCE. Usage Cited in: Exp Neurol. 2018 Jun;304:41-57.

    Western blotting images showing intracellular and surface AMPAR GluR2 expression in the CX546 treated group and the vehicle treated group.
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    CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. IC50 value: Target: AMPAR agonist in vitro: Treatments with the ampakine CX614 markedly and reversibly increased brain-derived neurotrophic factor (BDNF) mRNA and protein levels in cultured rat entorhinal/hippocampal slices [1]. in contrast to cyclothiazide or IDRA 21, the Ampakine CX546 binds specifically to the agonist bound nondesensitized receptor, most likely acting by destabilizing the desensitized receptor conformation [2]. In binding tests, CX546 caused an approximately 2-fold increase in the affinity for radiolabeled agonists, whereas CX516 was ineffective [3]. in vivo: Intraperitoneal injections of CX546 increased hippocampal BDNF mRNA levels in aged rats and middle-aged mice [1]. Administration of the positive modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPAR), CX546, during the conditioning phase only, improved the disrupted LI in mGluR5 knockout mice and facilitated LI in control C57BL/6J mice, given extended number of conditioning trails (four conditioning stimulus-unconditioned stimulus) [4].

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    Room temperature in continental US; may vary elsewhere.

    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    Ethanol : 100 mg/mL (404.38 mM; Need ultrasonic)

    H2O : 2 mg/mL (8.09 mM; Need ultrasonic)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.0438 mL 20.2192 mL 40.4384 mL
    5 mM 0.8088 mL 4.0438 mL 8.0877 mL
    10 mM 0.4044 mL 2.0219 mL 4.0438 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (10.11 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (10.11 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% EtOH    90% corn oil

      Solubility: ≥ 2.5 mg/mL (10.11 mM); Clear solution

    *All of the co-solvents are provided by MCE.

    Purity: 99.50%

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    CX546CX 546CX-546iGluRAutophagyIonotropic glutamate receptorsInhibitorinhibitorinhibit

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