1. Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. iGluR


Cat. No.: HY-12505 Purity: 99.50%
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CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.

For research use only. We do not sell to patients.

CX546 Chemical Structure

CX546 Chemical Structure

CAS No. : 215923-54-9

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10 mg USD 106 In-stock
Estimated Time of Arrival: December 31
50 mg USD 414 In-stock
Estimated Time of Arrival: December 31
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    CX546 purchased from MCE. Usage Cited in: Exp Neurol. 2018 Feb 24;304:41-57.

    Western blotting images showing intracellular and surface AMPAR GluR2 expression in the CX546 treated group and the vehicle treated group.
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    • Technical Information

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    • References


    CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. IC50 value: Target: AMPAR agonist in vitro: Treatments with the ampakine CX614 markedly and reversibly increased brain-derived neurotrophic factor (BDNF) mRNA and protein levels in cultured rat entorhinal/hippocampal slices [1]. in contrast to cyclothiazide or IDRA 21, the Ampakine CX546 binds specifically to the agonist bound nondesensitized receptor, most likely acting by destabilizing the desensitized receptor conformation [2]. In binding tests, CX546 caused an approximately 2-fold increase in the affinity for radiolabeled agonists, whereas CX516 was ineffective [3]. in vivo: Intraperitoneal injections of CX546 increased hippocampal BDNF mRNA levels in aged rats and middle-aged mice [1]. Administration of the positive modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors (AMPAR), CX546, during the conditioning phase only, improved the disrupted LI in mGluR5 knockout mice and facilitated LI in control C57BL/6J mice, given extended number of conditioning trails (four conditioning stimulus-unconditioned stimulus) [4].

    Solvent & Solubility
    In Vitro: 

    H2O : 2 mg/mL (8.09 mM; Need ultrasonic)

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.0438 mL 20.2192 mL 40.4384 mL
    5 mM 0.8088 mL 4.0438 mL 8.0877 mL
    10 mM 0.4044 mL 2.0219 mL 4.0438 mL
    *Please refer to the solubility information to select the appropriate solvent.
    Molecular Weight




    CAS No.




    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month

    Room temperature in continental US; may vary elsewhere

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    Cat. No.: HY-12505