2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Candesartan-d4

Candesartan-d4 (CV-11974-d4) is the deuterium labeled Candesartan (HY-B0205). Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).

Para uso exclusivo en investigación. No vendemos a pacientes.

Candesartan-d<sub>4</sub>

Candesartan-d4 Estructura química

No. CAS : 1346604-70-3

Tamaño Precio Stock Cantidad
1 mg En stock
5 mg   Obtener un presupuesto  
10 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 Customer Validation

Other Forms of Candesartan-d4:

Candesartan-d4 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Angiotensin Receptor:

Ver todas las isoformas
AT1 Receptor AT2 Receptor

  • Actividad biológica

  • Pureza y Documentación

  • Revisión del cliente

Descripciòn

Candesartan-d4 (CV-11974-d4) is the deuterium labeled Candesartan (HY-B0205). Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI).

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Candesartan-d4 Related Antibodies
Peso molecular

444.48

Fòrmula

C24H16D4N6O3
No. CAS
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

[2H]C1=C(CN2C(C(C(O)=O)=CC=C3)=C3N=C2OCC)C([2H])=C([2H])C(C4=CC=CC=C4C5=NNN=N5)=C1[2H]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : ≥ 30 mg/mL (67.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 30 mg/mL (67.49 mM)

Ethanol : ≥ 3 mg/mL (6.75 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2498 mL 11.2491 mL 22.4982 mL
5 mM 0.4500 mL 2.2498 mL 4.4996 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 98.85%

SDS (419 KB)

COA (261 KB) HNMR (113 KB) LCMS (100 KB)

Instrucciones de manejo (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO / DMF 1 mM 2.2498 mL 11.2491 mL 22.4982 mL 56.2455 mL
5 mM 0.4500 mL 2.2498 mL 4.4996 mL 11.2491 mL
DMSO / DMF 10 mM 0.2250 mL 1.1249 mL 2.2498 mL 5.6245 mL
15 mM 0.1500 mL 0.7499 mL 1.4999 mL 3.7497 mL
20 mM 0.1125 mL 0.5625 mL 1.1249 mL 2.8123 mL
25 mM 0.0900 mL 0.4500 mL 0.8999 mL 2.2498 mL
30 mM 0.0750 mL 0.3750 mL 0.7499 mL 1.8748 mL
40 mM 0.0562 mL 0.2812 mL 0.5625 mL 1.4061 mL
50 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1249 mL
60 mM 0.0375 mL 0.1875 mL 0.3750 mL 0.9374 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Candesartan-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Candesartan-d41346604-70-3CV-11974-d4Angiotensin ReceptorInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
Candesartan-d4
Cat. No.:
HY-B0205S
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (419 KB) Français - FR (419 KB) Deutsch - DE (419 KB) Norwegian - NO (419 KB) Español - ES (419 KB) Swedish - SV (419 KB) Italian - IT (419 KB) Korean - KR (419 KB) Portuguese - PT (419 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.