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Cyclen is a macrocyclic tetraamine chelating agent. Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates. Cyclen is employed as a structural regulator through interfacial polymerization of polyethleneimine (PEI) and trimesoyl chloride (TMC) to develop polyamide NF membrane with efficient Li+/Mg2+ separation performance. Cyclen has specific cavity structure and exhibits selective coordination properties for Li+ ions[1][2].

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Cyclen

Cyclen Estructura química

No. CAS : 294-90-6

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Other Forms of Cyclen:

Cyclen Related Antibodies

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Descripciòn

Cyclen is a macrocyclic tetraamine chelating agent. Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates. Cyclen is employed as a structural regulator through interfacial polymerization of polyethleneimine (PEI) and trimesoyl chloride (TMC) to develop polyamide NF membrane with efficient Li+/Mg2+ separation performance. Cyclen has specific cavity structure and exhibits selective coordination properties for Li+ ions[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
5 3
Compound: 8
Cytotoxicity against HEK cells
Cytotoxicity against HEK cells
[PMID: 18313921]
HEK293 EC50
5 3
Compound: 8
Cytotoxicity against HEK cells
Cytotoxicity against HEK cells
[PMID: 18313921]
In Vitro

Cyclen binds dehydrated Li+ with an adsorption energy of -75.0 kJ/mol, forming a stable complex due to a well-matched molecular cavity size[2].
Cyclen in PEI/Cyclen-TMC composite membrane reduces the Mg2+/Li+ mass ratio of simulated salt lake brine from 40 to 0.3 over three nanofiltration stages, achieving a 45.5% Li+ recovery rate and producing Li2CO3 with 93% purity after precipitation and filtration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclen Related Antibodies
Ensayo clínico
Peso molecular

172.28

Fòrmula

C8H20N4
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

C1CNCCNCCNCCN1
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvente y solubilidad
In Vitro: 

H2O : 50 mg/mL (290.23 mM; Need ultrasonic)

DMSO : 1.85 mg/mL (10.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8045 mL 29.0225 mL 58.0450 mL
5 mM 1.1609 mL 5.8045 mL 11.6090 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: 99.97%

SDS (786 KB)

COA (249 KB) HNMR (128 KB) MS (72 KB) GC (211 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.8045 mL 29.0225 mL 58.0450 mL 145.1126 mL
5 mM 1.1609 mL 5.8045 mL 11.6090 mL 29.0225 mL
10 mM 0.5805 mL 2.9023 mL 5.8045 mL 14.5113 mL
H2O 15 mM 0.3870 mL 1.9348 mL 3.8697 mL 9.6742 mL
20 mM 0.2902 mL 1.4511 mL 2.9023 mL 7.2556 mL
25 mM 0.2322 mL 1.1609 mL 2.3218 mL 5.8045 mL
30 mM 0.1935 mL 0.9674 mL 1.9348 mL 4.8371 mL
40 mM 0.1451 mL 0.7256 mL 1.4511 mL 3.6278 mL
50 mM 0.1161 mL 0.5805 mL 1.1609 mL 2.9023 mL
60 mM 0.0967 mL 0.4837 mL 0.9674 mL 2.4185 mL
80 mM 0.0726 mL 0.3628 mL 0.7256 mL 1.8139 mL
100 mM 0.0580 mL 0.2902 mL 0.5805 mL 1.4511 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclen294-90-6Biochemical Assay ReagentsDOTA12-crown-4 etherDO3AMg2+ ionspolyamide nanofiltration membranesMRI contrast agentsGd3+-chelatesLi+ ionsGd3+ ionslithium ionsInhibitorinhibitorinhibit

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Nombre del producto:
Cyclen
Cat. No.:
HY-W007656
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SAFETY DATA SHEET (SDS)

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