1. NF-κB
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  3. Flaconitine

Flaconitine (Synonyms: Acetylaconitine; 3-Acetylaconitine)

Cat. No.: HY-N0276 Purity: 98.92%
Handling Instructions

Flaconitine is considered to be a NF-κB inhibitor.

For research use only. We do not sell to patients.

Flaconitine Chemical Structure

Flaconitine Chemical Structure

CAS No. : 77181-26-1

Size Price Stock Quantity
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 135 In-stock
Estimated Time of Arrival: December 31
50 mg USD 340 In-stock
Estimated Time of Arrival: December 31
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Description

Flaconitine is considered to be a NF-κB inhibitor.

IC50 & Target[1]

NF-κB

 

In Vitro

Flaconitine has been demonstrated to suppress TNF-α induced NF-κB activation and is considered as a diester-diterpenoid-type NF-κB inhibitor[1] Flaconitine (3-Acetylaconitine) is evaluated for its cytotoxic activity against human leukemic P388 cells using the SRB (Sulforhodamine B) method, with Etoposide as the positive control. The cell growth inhibitory potency of Flaconitine is expressed as IC50 (μM) Value. Flaconitine exhibits moderately cytotoxic activity with an IC50 of 18.6 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

687.77

Formula

C₃₆H₄₉NO₁₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (72.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4540 mL 7.2699 mL 14.5397 mL
5 mM 0.2908 mL 1.4540 mL 2.9079 mL
10 mM 0.1454 mL 0.7270 mL 1.4540 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.63 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[2]

The assay is performed following a standard published procedure using microtiter plate format and sulforhodamine B standing at the end point. The leukemic cells (P388) are exposed to Flaconitine (3-Acetylaconitine) for three days. Cells are grown and maintained in an incubator set at 37°C, 5% CO2 and 95% humidity. RPMI-1640 media supplemented with 10% fetal calf serum (FCS) and 0.5% trypsin are used to culture P388 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Flaconitine
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