1. NF-κB
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  3. Flaconitine

Flaconitine (Synonyms: Acetylaconitine; 3-Acetylaconitine)

Cat. No.: HY-N0276
Handling Instructions

Flaconitine is isolated from the ammonium hydroxide wetted root of A.szechenyianum Gay. Flaconitine is considered to be a NF-κB inhibitor.

For research use only. We do not sell to patients.

Flaconitine Chemical Structure

Flaconitine Chemical Structure

CAS No. : 77181-26-1

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Flaconitine is isolated from the ammonium hydroxide wetted root of A.szechenyianum Gay. Flaconitine is considered to be a NF-κB inhibitor.

IC50 & Target[1]



In Vitro

Flaconitine has been demonstrated to suppress TNF-α induced NF-κB activation and is considered as a diester-diterpenoid-type NF-κB inhibitor[1] Flaconitine (3-Acetylaconitine) is evaluated for its cytotoxic activity against human leukemic P388 cells using the SRB (Sulforhodamine B) method, with Etoposide as the positive control. The cell growth inhibitory potency of Flaconitine is expressed as IC50 (μM) Value. Flaconitine exhibits moderately cytotoxic activity with an IC50 of 18.6 μM[2].

Molecular Weight







Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Cell Assay

The assay is performed following a standard published procedure using microtiter plate format and sulforhodamine B standing at the end point. The leukemic cells (P388) are exposed to Flaconitine (3-Acetylaconitine) for three days. Cells are grown and maintained in an incubator set at 37°C, 5% CO2 and 95% humidity. RPMI-1640 media supplemented with 10% fetal calf serum (FCS) and 0.5% trypsin are used to culture P388 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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FlaconitineAcetylaconitine3-AcetylaconitineNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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