2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. ATP Synthase Mitochondrial Metabolism
  4. Gboxin

Gboxin 

Cat. No.: HY-111651 Purity: 99.49%
COA Handling Instructions

Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity.

For research use only. We do not sell to patients.

Gboxin Chemical Structure

Gboxin Chemical Structure

CAS No. : 2101315-36-8

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 182 In-stock
Solution
10 mM * 1 mL in DMSO USD 182 In-stock
Solid
5 mg USD 165 In-stock
10 mg USD 275 In-stock
25 mg USD 605 In-stock
50 mg USD 1045 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Gboxin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Gboxin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity[1].

IC50 & Target

F0F1 ATP synthase[1]
In Vitro

Gboxin (0-15 μM; 96 hours) specifically inhibit the growth of primary ‘high-throughput GBM sphere’ (HTS) cells but not that of cycling primary low-passage mouse embryonic fibroblasts (MEFs) or astrocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gboxin Related Antibodies

Cell Viability Assay[1]

Cell Line: HTS cells, MEFs and astrocytes
Concentration: 0, 185, 555, 1667, 5000, 15000 nM
Incubation Time: 96 hours
Result: Inhibited the growth of HTS cells (IC50=150 nM).
Molecular Weight

392.96

Appearance

Solid

Formula

C22H33ClN2O2
CAS No.
SMILES

O=C(O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1)CN2C(CC)=[N+](C)C3=CC=CC=C23.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 32.5 mg/mL (82.71 mM; Need ultrasonic)

H2O : 10 mg/mL (25.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5448 mL 12.7239 mL 25.4479 mL
5 mM 0.5090 mL 2.5448 mL 5.0896 mL
10 mM 0.2545 mL 1.2724 mL 2.5448 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.17 mg/mL (5.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.17 mg/mL (5.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.17 mg/mL (5.52 mM); Clear solution

  • 4.

    Add each solvent one by one:  PBS

    Solubility: 2 mg/mL (5.09 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Gboxin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Gboxin2101315-36-8ATP SynthaseMitochondrial MetabolismInhibitorinhibitorinhibit

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