1. Membrane Transporter/Ion Channel
  2. ATP Synthase
  3. Gboxin

Gboxin 

Cat. No.: HY-111651 Purity: 99.32%
Handling Instructions

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity.

For research use only. We do not sell to patients.

Gboxin Chemical Structure

Gboxin Chemical Structure

CAS No. : 2101315-36-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase[1]. Antitumour activity[1].

IC50 & Target

F0F1 ATP synthase[1]

In Vitro

Gboxin (0-15 μM; 96 hours) specifically inhibit the growth of primary ‘high-throughput GBM sphere’ (HTS) cells but not that of cycling primary low-passage mouse embryonic fibroblasts (MEFs) or astrocytes[1].

Cell Viability Assay[1]

Cell Line: HTS cells, MEFs and astrocytes
Concentration: 0, 185, 555, 1667, 5000, 15000 nM
Incubation Time: 96 hours
Result: Inhibited the growth of HTS cells (IC50=150 nM).
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 32.5 mg/mL (82.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5448 mL 12.7239 mL 25.4479 mL
5 mM 0.5090 mL 2.5448 mL 5.0896 mL
10 mM 0.2545 mL 1.2724 mL 2.5448 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (5.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (5.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (5.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

392.96

Formula

C₂₂H₃₃ClN₂O₂

CAS No.

2101315-36-8

SMILES

O=C(O[[email protected]]1[[email protected]](C(C)C)CC[[email protected]@H](C)C1)CN2C(CC)=[N+](C)C3=CC=CC=C23.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Gboxin
Cat. No.:
HY-111651
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Gboxin

Cat. No.: HY-111651