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Ioversol (Synonyms: MP-328)

Cat. No.: HY-B1410 Purity: >98.0%
Handling Instructions

Ioversol is a nonionic iodinated contrast agent.

For research use only. We do not sell to patients.

Ioversol Chemical Structure

Ioversol Chemical Structure

CAS No. : 87771-40-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 120 In-stock
Estimated Time of Arrival: December 31
100 mg USD 168 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

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  • Technical Information

  • Purity & Documentation

  • References

Description

Ioversol is a nonionic iodinated contrast agent.

In Vitro

Ioversol (100 mg iodine/ml) exposure induces significantly increased lactate dehydrogenase release and decreased 3-(4,5-dimethyldiazol-2-yl)-2,5-diphenyl tetrazolium bromide conversion in NRK-52E cells. Ioversol significantly increases apoptosis and caspase-3 protein expression in the NRK-52E cells exposed to ioversol for 4 h. Ioversol treatment induces a significant increase in [Ca2+]i and intracellular ROS[1].

In Vivo

In comparison with iothalamate, ioversol has a greatly reduced propensity to stimulate the release of endothelin, from cultured cells and when injected into anesthetized rats. Ioversol produces less renal vasoconstriction than does iothalamate, in control and in USIC rats, and the development of radiocontrast nephropathy, assessed by creatinine clearance and morphologic damage to the renal medulla, is largely avoided[2].

Clinical Trial
Storage

4°C, protect from light

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (123.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2390 mL 6.1949 mL 12.3899 mL
5 mM 0.2478 mL 1.2390 mL 2.4780 mL
10 mM 0.1239 mL 0.6195 mL 1.2390 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Cell viability is assessed by using the MTT uptake assay. The conversion of MTT, a tetrazolium salt, into formazan depends on the activity of a group of mitochondrial dehydrogenases and, thus, is an indicator of cell metabolic activity. The color of MTT tetrazole salt is measured with a spectrophotometer at the wavelength of 570 nm. Briefly, fresh MTT solution (10 mg/mL in 1× PBS) is added (1:20 volume of medium) after removing the medium and the cells are incubated for 1.5 h. The cells are lysed and purple formazan dissolved into the solution by overnight incubation with MTT lysis buffer. The results are expressed as the percentage of undamaged control cells, assuming the absorbance of control wells as 100%.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

807.11

Formula

C₁₈H₂₄I₃N₃O₉

CAS No.

87771-40-2

SMILES

O=C(C1=C(I)C(N(C(CO)=O)CCO)=C(I)C(C(NCC(O)CO)=O)=C1I)NCC(O)CO

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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Ioversol

Cat. No.: HY-B1410