Larazotide acetate

Name: Larazotide acetate
Brand: MedChemExpress
SKU: HY-106268A
Rating: 4.5 (3 reviews)

製品番号: HY-106268A 純度: 99.74%: FAQs
Data Sheet SDS COA 取扱説明書

Molarity Calculator

Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC₅₀s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

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Larazotide acetate 構造式

CAS 番号 : 881851-50-9

容量	価格（税別）	在庫状況	数量
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 138	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 138	在庫あり	Estimated Time of Arrival: December 31
Solid
1 mg	USD 50	在庫あり	Estimated Time of Arrival: December 31
5 mg	USD 100	在庫あり	Estimated Time of Arrival: December 31
10 mg	USD 160	在庫あり	Estimated Time of Arrival: December 31
25 mg	USD 320	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Other Forms of Larazotide acetate:

Larazotide お問い合わせ

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製品説明

IC₅₀ & Target

Paracellular permeability^[1]

体外実験

Larazotide acetate (1-100 μM; 5 d) affects Vero cell growth^[1].
Larazotide acetate (1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC₅₀s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively^[1].
Larazotide acetate (1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells^[2].
Larazotide acetate (12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	Vero cell line
Concentration:	1-100 μM
Incubation Time:	5 days
Result:	Inhibited Vero cell growth with an CC₅₀ value of 82.5 μM.

体内実験

Larazotide acetate (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HLA-HCD4/DQ8 double transgenic mice^[2]
Dosage:	250 μg
Administration:	Intraperitoneal injection; 250 μg twice a week for 7 weeks
Result:	Improved barrier function parameters and reduced macrophage counts in the lamina propria to control levels.

臨床実験

分子量

785.89

分子式

C₃₄H₅₉N₉O₁₂

CAS 番号

881851-50-9

Appearance

Solid

Color

White to off-white

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Sealed storage, away from moisture
Powder	-80°C	2 years
	-20°C	1 year
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : 16.67 mg/mL (21.21 mM; Need ultrasonic)

DMSO : 3.2 mg/mL (4.07 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2724 mL	6.3622 mL	12.7244 mL
5 mM	0.2545 mL	1.2724 mL	2.5449 mL
10 mM	0.1272 mL	0.6362 mL	1.2724 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (127.24 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.74%

Select Batch:

データシート (277 KB) SDS (0 KB)

COA (251 KB) LCMS (87 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Di Micco S, et al. Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. Int J Mol Sci. 2021 Aug 30;22(17):9427. [Content Brief]

[2]. Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.2724 mL	6.3622 mL	12.7244 mL	31.8111 mL
H₂O	5 mM	0.2545 mL	1.2724 mL	2.5449 mL	6.3622 mL
	10 mM	0.1272 mL	0.6362 mL	1.2724 mL	3.1811 mL
	15 mM	0.0848 mL	0.4241 mL	0.8483 mL	2.1207 mL
	20 mM	0.0636 mL	0.3181 mL	0.6362 mL	1.5906 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.