2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Losartan-d4

Losartan-d4 is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

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Losartan-d<sub>4</sub>

Losartan-d4 Estructura química

No. CAS : 1030937-27-9

Tamaño Precio Stock Cantidad
1 mg En stock
5 mg En stock
10 mg   Obtener un presupuesto  
50 mg   Obtener un presupuesto  

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Other Forms of Losartan-d4:

Losartan-d4 Related Antibodies

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AT1 Receptor AT2 Receptor

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Descripciòn

Losartan-d4 is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC50 & Target

AT1 Receptor

 

Peso molecular

426.94

Fòrmula

C22H19D4ClN6O
No. CAS
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

OCC1=C(Cl)N=C(CCCC)N1CC2=C([2H])C([2H])=C(C3=CC=CC=C3C4=NNN=N4)C([2H])=C2[2H]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

Ethanol : ≥ 42.69 mg/mL (99.99 mM)

DMSO : ≥ 42.69 mg/mL (99.99 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3422 mL 11.7112 mL 23.4225 mL
5 mM 0.4684 mL 2.3422 mL 4.6845 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.3422 mL 11.7112 mL 23.4225 mL 58.5562 mL
5 mM 0.4684 mL 2.3422 mL 4.6845 mL 11.7112 mL
10 mM 0.2342 mL 1.1711 mL 2.3422 mL 5.8556 mL
15 mM 0.1561 mL 0.7807 mL 1.5615 mL 3.9037 mL
20 mM 0.1171 mL 0.5856 mL 1.1711 mL 2.9278 mL
25 mM 0.0937 mL 0.4684 mL 0.9369 mL 2.3422 mL
30 mM 0.0781 mL 0.3904 mL 0.7807 mL 1.9519 mL
40 mM 0.0586 mL 0.2928 mL 0.5856 mL 1.4639 mL
50 mM 0.0468 mL 0.2342 mL 0.4684 mL 1.1711 mL
60 mM 0.0390 mL 0.1952 mL 0.3904 mL 0.9759 mL
80 mM 0.0293 mL 0.1464 mL 0.2928 mL 0.7320 mL
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Losartan-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Losartan-d41030937-27-9DuP-753 d4Angiotensin ReceptorInhibitorinhibitorinhibit

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Nombre del producto:
Losartan-d4
Cat. No.:
HY-17512S
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