Losartan-d4 (carboxylic acid)
Based on 1 Customer Validation
Losartan-d4 carboxylic acid (E-3174-d4) is the deuterium labeled Losartan Carboxylic Acid (HY-12765). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
For research use only. We do not sell to patients.
- Purity: 98.09%
- CAS No.: 1246820-62-1
- Formula: C22H17D4ClN6O2
- Molecular Weight:440.92
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1246820-62-1
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Unlabeled Cas 124750-92-1
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Appearance Solid
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Molecular Weight 440.92
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Formula C22H17D4ClN6O2
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Color Off-white to light yellow
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SMILES
ClC1=C(C(O)=O)N(CC2=C([2H])C([2H])=C(C3=CC=CC=C3C4=NN=NN4)C([2H])=C2[2H])C(CCCC)=N1
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Synonyms
E-3174 d4; EXP-3174 d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 250 mg/mL (567.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (252 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2680 mL | 11.3399 mL | 22.6799 mL | 56.6996 mL |
| 5 mM | 0.4536 mL | 2.2680 mL | 4.5360 mL | 11.3399 mL | |
| 10 mM | 0.2268 mL | 1.1340 mL | 2.2680 mL | 5.6700 mL | |
| 15 mM | 0.1512 mL | 0.7560 mL | 1.5120 mL | 3.7800 mL | |
| 20 mM | 0.1134 mL | 0.5670 mL | 1.1340 mL | 2.8350 mL | |
| 25 mM | 0.0907 mL | 0.4536 mL | 0.9072 mL | 2.2680 mL | |
| 30 mM | 0.0756 mL | 0.3780 mL | 0.7560 mL | 1.8900 mL | |
| 40 mM | 0.0567 mL | 0.2835 mL | 0.5670 mL | 1.4175 mL | |
| 50 mM | 0.0454 mL | 0.2268 mL | 0.4536 mL | 1.1340 mL | |
| 60 mM | 0.0378 mL | 0.1890 mL | 0.3780 mL | 0.9450 mL | |
| 80 mM | 0.0283 mL | 0.1417 mL | 0.2835 mL | 0.7087 mL | |
| 100 mM | 0.0227 mL | 0.1134 mL | 0.2268 mL | 0.5670 mL |
Losartan-d4 (carboxylic acid) Related Classifications
HY-12765S Related Classifications
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