1. GPCR/G Protein
  2. Angiotensin Receptor
  3. Olodanrigan

Olodanrigan (Synonyms: EMA401; PD-126055)

Cat. No.: HY-13106 Purity: 99.29%
Handling Instructions

Olodanrigan (EMA401), a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

For research use only. We do not sell to patients.

Olodanrigan Chemical Structure

Olodanrigan Chemical Structure

CAS No. : 1316755-16-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 95 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 85 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
25 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 440 In-stock
Estimated Time of Arrival: December 31
100 mg USD 740 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Olodanrigan (EMA401), a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

In Vivo

EMA401 (10 mg/kg; p.o.) results in a significant attenuation of theta power and increase in paw withdrawal latencies (PWL) in rats at day 14 after chronic constriction injury (CCI)[4].

Molecular Weight

507.58

Formula

C₃₂H₂₉NO₅

CAS No.

1316755-16-4

SMILES

O=C([[email protected]]1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(C(OCC5=CC=CC=C5)=C(OC)C=C4)C1)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (66.98 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9701 mL 9.8507 mL 19.7013 mL
5 mM 0.3940 mL 1.9701 mL 3.9403 mL
10 mM 0.1970 mL 0.9851 mL 1.9701 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Olodanrigan
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HY-13106
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