2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. Mapracorat

Mapracorat  (Synonyms: ZK-245186; BOL-303242X)

製品番号: HY-14864 純度: 99.40% ee.: 99.83%
COA 取扱説明書 Technical Support

Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Mapracorat

Mapracorat 構造式

CAS 番号 : 887375-26-0

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 661 在庫あり
Solution
10 mM * 1 mL in DMSO USD 661 在庫あり
Solid
5 mg $650 在庫あり
10 mg $950 在庫あり
25 mg $1800 在庫あり
50 mg $2800 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Mapracorat:

Mapracorat 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist.

体外実験

Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mapracorat 関連抗体
体内実験

Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
分子量

462.48

分子式

C25H26F4N2O2
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(C)(C1=C(OCC2)C2=CC(F)=C1)C[C@@](O)(CNC3=C4C=CC(C)=NC4=CC=C3)C(F)(F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 33.6 mg/mL (72.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1623 mL 10.8113 mL 21.6226 mL
5 mM 0.4325 mL 2.1623 mL 4.3245 mL
10 mM 0.2162 mL 1.0811 mL 2.1623 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.40% ee.: 99.83%

COA (249 KB) HNMR (203 KB) NP-HPLC (171 KB) LCMS (117 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1623 mL 10.8113 mL 21.6226 mL 54.0564 mL
5 mM 0.4325 mL 2.1623 mL 4.3245 mL 10.8113 mL
10 mM 0.2162 mL 1.0811 mL 2.1623 mL 5.4056 mL
15 mM 0.1442 mL 0.7208 mL 1.4415 mL 3.6038 mL
20 mM 0.1081 mL 0.5406 mL 1.0811 mL 2.7028 mL
25 mM 0.0865 mL 0.4325 mL 0.8649 mL 2.1623 mL
30 mM 0.0721 mL 0.3604 mL 0.7208 mL 1.8019 mL
40 mM 0.0541 mL 0.2703 mL 0.5406 mL 1.3514 mL
50 mM 0.0432 mL 0.2162 mL 0.4325 mL 1.0811 mL
60 mM 0.0360 mL 0.1802 mL 0.3604 mL 0.9009 mL
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Mapracorat Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mapracorat887375-26-0ZK-245186 BOL-303242XZK245186ZK 245186Glucocorticoid ReceptorInhibitorinhibitorinhibit

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製品名:
Mapracorat
製品番号:
HY-14864
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