1. GPCR/G Protein
  2. Glucocorticoid Receptor

(S)-Mapracorat (Synonyms: (S)-ZK-245186; (S)-BOL-303242X)

Cat. No.: HY-14864A Purity: 99.03% ee.: 98.79%
Handling Instructions

(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.

For research use only. We do not sell to patients.

(S)-Mapracorat Chemical Structure

(S)-Mapracorat Chemical Structure

CAS No. : 887375-15-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 715 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Other Forms of (S)-Mapracorat:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.

In Vitro

(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.

In Vivo

Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50.6 mg/mL (109.41 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1623 mL 10.8113 mL 21.6226 mL
5 mM 0.4325 mL 2.1623 mL 4.3245 mL
10 mM 0.2162 mL 1.0811 mL 2.1623 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

462.48

Formula

C₂₅H₂₆F₄N₂O₂

CAS No.

887375-15-7

SMILES

CC(C)(C1=C(OCC2)C2=CC(F)=C1)C[[email protected]](O)(CNC3=C4C=CC(C)=NC4=CC=C3)C(F)(F)F

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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× = ×
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Product Name:
(S)-Mapracorat
Cat. No.:
HY-14864A
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(S)-Mapracorat

Cat. No.: HY-14864A