1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Mapracorat

Mapracorat (Synonyms: ZK-245186; BOL-303242X)

Cat. No.: HY-14864 Purity: 99.40% ee.: 99.84%
Handling Instructions

Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist.

For research use only. We do not sell to patients.

Mapracorat Chemical Structure

Mapracorat Chemical Structure

CAS No. : 887375-26-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 715 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Other Forms of Mapracorat:

Top Publications Citing Use of Products
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Description

Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist.

In Vitro

Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.

In Vivo

Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33.6 mg/mL (72.65 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1623 mL 10.8113 mL 21.6226 mL
5 mM 0.4325 mL 2.1623 mL 4.3245 mL
10 mM 0.2162 mL 1.0811 mL 2.1623 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

462.48

Formula

C₂₅H₂₆F₄N₂O₂

CAS No.

887375-26-0

SMILES

CC(C)(C1=C(OCC2)C2=CC(F)=C1)C[[email protected]@](O)(CNC3=C4C=CC(C)=NC4=CC=C3)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Mapracorat
Cat. No.:
HY-14864
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Mapracorat

Cat. No.: HY-14864