N3-PEG3-vc-PAB-MMAE 

N3-PEG3-vc-PAB-MMAE is a synthesized agent-linker conjugate for ADC that incorporates the MMAE (a tubulin inhibitor ) and 3-unit PEG linker. N3-PEG3-vc-PAB-MMAE shows potent antitumor activity. N3-PEG3-vc-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of Dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1352.66

C₆₇H₁₀₉N₁₃O₁₆

3046395-46-1

Solid

White to off-white

O=C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)[C@@H]([C@@H](OC)[C@H](CCC2)N2C(C[C@H]([C@H](N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)C=C3)=O)C)=O)=O)C)[C@H](CC)C)OC)=O)C

Room temperature in continental US; may vary elsewhere.

*The compound is unstable in solutions, freshly prepared is recommended.