Onvansertib (Synonyms: NMS-1286937; NMS-P937)

Name: Onvansertib
Brand: MedChemExpress
SKU: HY-15828
Rating: 5.0 (10 reviews)

Cat. No.: HY-15828 Purity: 99.86%: Data Sheet
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NMS-1286937 is a potent, selective and orally available PLK1 inhibitor, with an IC₅₀ of 2 nM.

For research use only. We do not sell to patients.

CAS No. : 1034616-18-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 10 publication(s) in Google Scholar

10 Publications Citing Use of MCE Onvansertib

Cell Proliferation/Viability Assay

Cell Imaging/Staining

In Vivo Efficacy Study

: Onvansertib purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Oct 23;14(10):695. [Abstract]; T98G and U118 cells treated with onvansertib (2 nM) or MLN0905 (2 nM) were subjected to IP and IB with the indicated antibodies.

: Onvansertib purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2023 Oct 23;14(10):695. [Abstract]; PLA assay between TRIM26 and GPX4 in U118 cells treated with onvansertib (2 nM) or MLN0905 (2 nM).

: Onvansertib purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2023 Oct 15:957:176004. [Abstract]; The combined apoptotic effect of VS-5584 and Onvansertib (NMS-P937: 60 nM) on A549 cells.

: Onvansertib purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2023 Oct 15:957:176004. [Abstract]; The effect of VS-5584 in combination with Onvansertib (NMS-P937) on ROS levels in A549 cells. A549 cells were treated with 60 nM VS-5584 and/or 60 nM NMS-P937 for 48 h.

: Onvansertib purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2023 Oct 15:957:176004. [Abstract]; Representative images of xenografts undergoing VS-5584 (25 mg/kg/d) and/or Onvansertib (NMS-P937) (60 mg/kg/d) treatment.

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Description

NMS-1286937 is a potent, selective and orally available PLK1 inhibitor, with an IC₅₀ of 2 nM.

IC₅₀ & Target^[1]

PLK1

2 nM (IC₅₀)

FLT3

510 nM (IC₅₀)

MELK

744 nM (IC₅₀)

CK2

826 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
1A9	IC₅₀	0.062 μM Compound: NMS-P937	Antiproliferative activity against human 1A9 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human 1A9 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
1A9/ptx-22	IC₅₀	0.065 μM Compound: NMS-P937	Antiproliferative activity against human 1A9/ptx-22 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human 1A9/ptx-22 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
697	IC₅₀	0.026 μM Compound: NMS-P937	Antiproliferative activity against human 697 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human 697 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
786-0	IC₅₀	0.129 μM Compound: NMS-P937	Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
A-375	IC₅₀	0.04 μM Compound: NMS-P937	Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
A-431	IC₅₀	0.059 μM Compound: NMS-P937	Antiproliferative activity against human A-431 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human A-431 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
A2780	IC₅₀	0.04 μM Compound: NMS-P937	Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
A2780	IC₅₀	0.042 μM Compound: 7g	Antiproliferative activity against human A2780 cells Antiproliferative activity against human A2780 cells	[PMID: 21470862]
A2780 ADR	IC₅₀	0.62 μM Compound: NMS-P937	Antiproliferative activity against human A2780 ADR cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human A2780 ADR cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
A2780cis	IC₅₀	0.048 μM Compound: NMS-P937	Antiproliferative activity against human A2780cis cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human A2780cis cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
A498	IC₅₀	1.067 μM Compound: NMS-P937	Antiproliferative activity against human A498 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human A498 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
A549	IC₅₀	0.175 μM Compound: NMS-P937	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
ACHN	IC₅₀	0.429 μM Compound: NMS-P937	Antiproliferative activity against human ACHN cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human ACHN cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
AU565	IC₅₀	0.011 μM Compound: NMS-P937	Antiproliferative activity against human AU565 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human AU565 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
BT-20	IC₅₀	0.093 μM Compound: NMS-P937	Antiproliferative activity against human BT-20 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human BT-20 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
BT-474	IC₅₀	0.156 μM Compound: NMS-P937	Antiproliferative activity against human BT-474 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human BT-474 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
BT-549	IC₅₀	0.049 μM Compound: NMS-P937	Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
BXPC-3	IC₅₀	0.117 μM Compound: NMS-P937	Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
C-33-A	IC₅₀	0.061 μM Compound: NMS-P937	Antiproliferative activity against human C-33-A cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human C-33-A cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
CAKI-1	IC₅₀	0.515 μM Compound: NMS-P937	Antiproliferative activity against human CAKI-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human CAKI-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
CAKI-2	IC₅₀	0.083 μM Compound: NMS-P937	Antiproliferative activity against human CAKI-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human CAKI-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
CAL-12T	IC₅₀	0.191 μM Compound: NMS-P937	Antiproliferative activity against human CAL-12T cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human CAL-12T cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
CAL-51	IC₅₀	0.019 μM Compound: NMS-P937	Antiproliferative activity against human CAL-51 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human CAL-51 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
CAMA-1	IC₅₀	0.35 μM Compound: NMS-P937	Antiproliferative activity against human CAMA-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human CAMA-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
CAPAN-1	IC₅₀	0.237 μM Compound: NMS-P937	Antiproliferative activity against human CAPAN-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human CAPAN-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
CCRF-CEM	IC₅₀	0.055 μM Compound: NMS-P937	Antiproliferative activity against human CCRF-CEM cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human CCRF-CEM cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
COLO 205	IC₅₀	0.032 μM Compound: NMS-P937	Antiproliferative activity against human COLO 205 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human COLO 205 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
COLO 320	IC₅₀	0.192 μM Compound: NMS-P937	Antiproliferative activity against human COLO 320 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human COLO 320 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
COLO-678	IC₅₀	0.354 μM Compound: NMS-P937	Antiproliferative activity against human COLO-678 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human COLO-678 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
COLO-741	IC₅₀	0.108 μM Compound: NMS-P937	Antiproliferative activity against human COLO-741 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human COLO-741 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
Caco-2	IC₅₀	4.765 μM Compound: NMS-P937	Antiproliferative activity against human Caco-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human Caco-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
Calu-3	IC₅₀	0.629 μM Compound: NMS-P937	Antiproliferative activity against human Calu-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human Calu-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
DLD-1	IC₅₀	0.329 μM Compound: NMS-P937	Antiproliferative activity against human DLD-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human DLD-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
DU-145	IC₅₀	0.252 μM Compound: NMS-P937	Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
DU-4475	IC₅₀	0.047 μM Compound: NMS-P937	Antiproliferative activity against human DU-4475 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human DU-4475 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
EKVX	IC₅₀	0.196 μM Compound: NMS-P937	Antiproliferative activity against human EKVX cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human EKVX cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
EVSA-T	IC₅₀	0.041 μM Compound: NMS-P937	Antiproliferative activity against human EVSA-T cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human EVSA-T cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
Granta-519	IC₅₀	0.029 μM Compound: NMS-P937	Antiproliferative activity against human Granta-519 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human Granta-519 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HCC 2998	IC₅₀	0.132 μM Compound: NMS-P937	Antiproliferative activity against human HCC 2998 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HCC 2998 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HCC1395	IC₅₀	0.049 μM Compound: NMS-P937	Antiproliferative activity against human HCC1395 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HCC1395 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HCC1419	IC₅₀	0.042 μM Compound: NMS-P937	Antiproliferative activity against human HCC1419 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HCC1419 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HCC1806	IC₅₀	0.018 μM Compound: NMS-P937	Antiproliferative activity against human HCC1806 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HCC1806 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HCC1937	IC₅₀	0.595 μM Compound: NMS-P937	Antiproliferative activity against human HCC1937 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HCC1937 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HCC1954	IC₅₀	0.015 μM Compound: NMS-P937	Antiproliferative activity against human HCC1954 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HCC1954 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HCC70	IC₅₀	0.279 μM Compound: NMS-P937	Antiproliferative activity against human HCC70 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HCC70 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HCC78	IC₅₀	0.34 μM Compound: NMS-P937	Antiproliferative activity against human HCC78 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HCC78 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HCT-116	IC₅₀	0.086 μM Compound: NMS-P937	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HCT-15	IC₅₀	0.156 μM Compound: NMS-P937	Antiproliferative activity against human HCT-15 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HCT-15 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HDQ-P1	IC₅₀	0.051 μM Compound: NMS-P937	Antiproliferative activity against human HDQ-P1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HDQ-P1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HEL	IC₅₀	0.048 μM Compound: NMS-P937	Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HL-60	IC₅₀	0.073 μM Compound: NMS-P937	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HOP-62	IC₅₀	0.209 μM Compound: NMS-P937	Antiproliferative activity against human HOP-62 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HOP-62 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HOP-92	IC₅₀	0.283 μM Compound: NMS-P937	Antiproliferative activity against human HOP-92 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HOP-92 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HT-1080	IC₅₀	0.059 μM Compound: NMS-P937	Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HT-29	IC₅₀	0.039 μM Compound: NMS-P937	Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HT1197	IC₅₀	10 μM Compound: NMS-P937	Antiproliferative activity against human HT1197 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HT1197 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
HeLa	IC₅₀	0.06 μM Compound: NMS-P937	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
Hs-578T	IC₅₀	0.251 μM Compound: NMS-P937	Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human Hs-578T cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
IGROV-1	IC₅₀	0.054 μM Compound: NMS-P937	Antiproliferative activity against human IGROV-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human IGROV-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
JIMT-1	IC₅₀	0.105 μM Compound: NMS-P937	Antiproliferative activity against human JIMT-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human JIMT-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
Jurkat	IC₅₀	0.048 μM Compound: NMS-P937	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
K562	IC₅₀	0.087 μM Compound: NMS-P937	Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
KARPAS-299	IC₅₀	0.053 μM Compound: NMS-P937	Antiproliferative activity against human KARPAS-299 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human KARPAS-299 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
KG-1	IC₅₀	0.058 μM Compound: NMS-P937	Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
KM12	IC₅₀	0.277 μM Compound: NMS-P937	Antiproliferative activity against human KM12 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human KM12 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
KMS-11	IC₅₀	0.046 μM Compound: NMS-P937	Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human KMS-11 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
L-363	IC₅₀	0.037 μM Compound: NMS-P937	Antiproliferative activity against human L-363 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human L-363 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
LCLC-97TM1	IC₅₀	0.032 μM Compound: NMS-P937	Antiproliferative activity against human LCLC-97TM1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human LCLC-97TM1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
LN-229	IC₅₀	0.062 μM Compound: NMS-P937	Antiproliferative activity against human LN-229 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human LN-229 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
LNCaP	IC₅₀	0.082 μM Compound: NMS-P937	Antiproliferative activity against human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human LNCaP cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
LP-1	IC₅₀	0.059 μM Compound: NMS-P937	Antiproliferative activity against human LP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human LP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
LS174T	IC₅₀	0.164 μM Compound: NMS-P937	Antiproliferative activity against human LS174T cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human LS174T cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
LS180	IC₅₀	0.192 μM Compound: NMS-P937	Antiproliferative activity against human LS180 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human LS180 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
LoVo	IC₅₀	0.065 μM Compound: NMS-P937	Antiproliferative activity against human LoVo cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human LoVo cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
M14	IC₅₀	0.067 μM Compound: NMS-P937	Antiproliferative activity against human M14 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human M14 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
MDA-MB-231	IC₅₀	0.172 μM Compound: NMS-P937	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
MDA-MB-435S	IC₅₀	0.023 μM Compound: NMS-P937	Antiproliferative activity against human MDA-MB-435S cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human MDA-MB-435S cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
MDA-MB-436	IC₅₀	0.093 μM Compound: NMS-P937	Antiproliferative activity against human MDA-MB-436 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human MDA-MB-436 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
MDA-MB-453	IC₅₀	0.09 μM Compound: NMS-P937	Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
MDA-MB-468	IC₅₀	0.083 μM Compound: NMS-P937	Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
MFM-223	IC₅₀	0.01 μM Compound: NMS-P937	Antiproliferative activity against human MFM-223 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human MFM-223 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
MIA PaCa-2	IC₅₀	0.112 μM Compound: NMS-P937	Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
MOLM-13	IC₅₀	0.022 μM Compound: NMS-P937	Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
MOLT-4	IC₅₀	0.045 μM Compound: NMS-P937	Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
MV4-11	IC₅₀	0.058 μM Compound: NMS-P937	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
MeWo	IC₅₀	0.237 μM Compound: NMS-P937	Antiproliferative activity against human MeWo cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human MeWo cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NALM-6	IC₅₀	0.061 μM Compound: NMS-P937	Antiproliferative activity against human NALM-6 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NALM-6 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H1299	IC₅₀	0.347 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H1299 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H1437	IC₅₀	0.039 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H1437 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H1437 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H146	IC₅₀	0.339 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H146 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H146 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H1650	IC₅₀	2.419 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H1650 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H1650 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H1770	IC₅₀	0.068 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H1770 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H1770 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H1975	IC₅₀	0.398 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H1993	IC₅₀	0.287 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H1993 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H1993 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H2170	IC₅₀	0.015 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H2170 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H2170 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H2228	IC₅₀	0.335 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H2228 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H2228 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H23	IC₅₀	0.056 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H23 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H23 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H322M	IC₅₀	0.183 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H322M cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H322M cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H358	IC₅₀	0.175 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H460	IC₅₀	0.109 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H520	IC₅₀	0.073 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H520 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H520 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H522	IC₅₀	0.034 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H522 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H522 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H526	IC₅₀	0.031 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H526 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H526 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H82	IC₅₀	0.016 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H82 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H82 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H838	IC₅₀	0.119 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H838 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H838 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H889	IC₅₀	0.135 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H889 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H889 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI-H929	IC₅₀	0.063 μM Compound: NMS-P937	Antiproliferative activity against human NCI-H929 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI-H929 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
NCI/ADR-RES	IC₅₀	1.214 μM Compound: NMS-P937	Antiproliferative activity against human NCI/ADR-RES cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human NCI/ADR-RES cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
OPM-2	IC₅₀	0.038 μM Compound: NMS-P937	Antiproliferative activity against human OPM-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human OPM-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
OVCAR-3	IC₅₀	0.041 μM Compound: NMS-P937	Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human OVCAR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
OVCAR-8	IC₅₀	0.059 μM Compound: NMS-P937	Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human OVCAR-8 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
PANC-1	IC₅₀	0.184 μM Compound: NMS-P937	Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
PC-3	IC₅₀	0.152 μM Compound: NMS-P937	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
RERF-LC-AI	IC₅₀	0.09 μM Compound: NMS-P937	Antiproliferative activity against human RERF-LC-AI cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human RERF-LC-AI cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
RO82-W-1	IC₅₀	0.837 μM Compound: NMS-P937	Antiproliferative activity against human RO82-W-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human RO82-W-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
RPMI-8226	IC₅₀	0.128 μM Compound: NMS-P937	Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
RS4-11	IC₅₀	0.043 μM Compound: NMS-P937	Antiproliferative activity against human RS4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human RS4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SAOS-2	IC₅₀	0.045 μM Compound: NMS-P937	Antiproliferative activity against human SAOS-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SAOS-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SET-2	IC₅₀	0.145 μM Compound: NMS-P937	Antiproliferative activity against human SET2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SET2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SF-268	IC₅₀	0.09 μM Compound: NMS-P937	Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SF-268 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SF-295	IC₅₀	0.386 μM Compound: NMS-P937	Antiproliferative activity against human SF-295 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SF-295 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SF-539	IC₅₀	0.047 μM Compound: NMS-P937	Antiproliferative activity against human SF-539 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SF-539 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SH-SY5Y	IC₅₀	0.03 μM Compound: NMS-P937	Antiproliferative activity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SH-SY5Y cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SK-BR-3	IC₅₀	0.035 μM Compound: NMS-P937	Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SK-LU-1	IC₅₀	0.443 μM Compound: NMS-P937	Antiproliferative activity against human SK-LU-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SK-LU-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SK-MEL-2	IC₅₀	0.256 μM Compound: NMS-P937	Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SK-MEL-2 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SK-MEL-28	IC₅₀	0.078 μM Compound: NMS-P937	Antiproliferative activity against human SK-MEL-28 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SK-MEL-28 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SK-MEL-5	IC₅₀	0.513 μM Compound: NMS-P937	Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SK-MEL-5 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SK-MES-1	IC₅₀	0.367 μM Compound: NMS-P937	Antiproliferative activity against human SK-MES-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SK-MES-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SK-N-MC	IC₅₀	0.073 μM Compound: NMS-P937	Antiproliferative activity against human SK-N-MC cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SK-N-MC cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SK-OV-3	IC₅₀	0.191 μM Compound: NMS-P937	Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SKM-1	IC₅₀	0.06 μM Compound: NMS-P937	Antiproliferative activity against human SKM-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SKM-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SN12C	IC₅₀	0.062 μM Compound: NMS-P937	Antiproliferative activity against human SN12C cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SN12C cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SNB-19	IC₅₀	0.224 μM Compound: NMS-P937	Antiproliferative activity against human SNB-19 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SNB-19 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SR	IC₅₀	0.047 μM Compound: NMS-P937	Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SU-DHL-1	IC₅₀	0.096 μM Compound: NMS-P937	Antiproliferative activity against human SU-DHL-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SU-DHL-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SU-DHL-6	IC₅₀	0.05 μM Compound: NMS-P937	Antiproliferative activity against human SU-DHL-6 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SU-DHL-6 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SU-DHL-8	IC₅₀	0.031 μM Compound: NMS-P937	Antiproliferative activity against human SU-DHL-8 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SU-DHL-8 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SU-DHL10	IC₅₀	0.043 μM Compound: NMS-P937	Antiproliferative activity against human SU-DHL-10 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SU-DHL-10 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SUD4	IC₅₀	0.056 μM Compound: NMS-P937	Antiproliferative activity against human SU-DHL-4 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SU-DHL-4 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SUP-B15	IC₅₀	10 μM Compound: NMS-P937	Antiproliferative activity against human SUP-B15 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SUP-B15 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SW-620	IC₅₀	0.037 μM Compound: NMS-P937	Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SW1417	IC₅₀	0.606 μM Compound: NMS-P937	Antiproliferative activity against human SW1417 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SW1417 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SW48	IC₅₀	0.032 μM Compound: NMS-P937	Antiproliferative activity against human SW48 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SW48 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SW480	IC₅₀	0.618 μM Compound: NMS-P937	Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
SW948	IC₅₀	0.124 μM Compound: NMS-P937	Antiproliferative activity against human SW948 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human SW948 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
T84	IC₅₀	0.174 μM Compound: NMS-P937	Antiproliferative activity against human T84 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human T84 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
T98G	IC₅₀	0.228 μM Compound: NMS-P937	Antiproliferative activity against human T98G cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human T98G cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
THP-1	IC₅₀	0.032 μM Compound: NMS-P937	Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
TK-10	IC₅₀	1.206 μM Compound: NMS-P937	Antiproliferative activity against human TK-10 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human TK-10 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
Toledo	IC₅₀	0.042 μM Compound: NMS-P937	Antiproliferative activity against human Toledo cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human Toledo cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
U-118-MG	IC₅₀	0.22 μM Compound: NMS-P937	Antiproliferative activity against human U-118-MG cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human U-118-MG cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
U-251	IC₅₀	0.19 μM Compound: NMS-P937	Antiproliferative activity against human U-251 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human U-251 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
U-266	IC₅₀	0.04 μM Compound: NMS-P937	Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
U-87MG ATCC	IC₅₀	0.991 μM Compound: NMS-P937	Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
U-937	IC₅₀	0.041 μM Compound: NMS-P937	Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
U2OS	IC₅₀	0.285 μM Compound: NMS-P937	Antiproliferative activity against human U2OS cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human U2OS cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
UACC-257	IC₅₀	0.441 μM Compound: NMS-P937	Antiproliferative activity against human UACC-257 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human UACC-257 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
UACC-62	IC₅₀	0.103 μM Compound: NMS-P937	Antiproliferative activity against human UACC-62 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human UACC-62 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]
UO-31	IC₅₀	1.134 μM Compound: NMS-P937	Antiproliferative activity against human UO-31 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay Antiproliferative activity against human UO-31 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo assay	[PMID: 22319201]

In Vitro

NMS-1286937 is a potent, selective and orally available PLK1 inhibitor, with IC₅₀ of 2 nM. NMS-1286937 also shows inhibitory activities against FLT3, MELK, and CK2, with IC₅₀s of 510, 744, and 826 nM, respectively^[1]. NMS-P937 possesses a pure ATP competitive mechanism with a reversible dissociation and no time dependency. NMS-P937 (10 μM) is selective with a marginal activity of 48% and 40% inhibition on PLK2 and PLK3, respectively. NMS-P937 shows antiproliferative activity against a panel of 137 cell lines, with IC₅₀ values of below 100 nM for 60 of 137 cell lines and higher than 1 μM for only 9 of 137 cell lines^[2]. NMS-P937 shows cytotoxic activity against AmL-NS8 cells with IC₅₀ of 36 nM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NMS-1286937 (45 mg/kg, i.v.) shows a good tumor growth inhibition with acceptable and reversible body weight loss in CD1 nu/nu mice xenografted with human HCT116 colon adenocarcinoma cells. NMS-1286937 (60 mg/kg, p.o.) also inhibits the growth of tumor on HCT116 xenograft model^[1]. NMS-P937 (45 mg/kg, i.v.or 60 mg/kg, p.o) inhibits tumor growth to a comparable degree (TGI, 83% and 79% intravenously and orally, respectively) in HCT116-bearing mice. The combination of NMS-P937 (120 mg/kg given for 4 cycles of 2 consecutive days with 10-day rest) and cytarabine (75 mg/kg for 4 cycles of 5 consecutive days with 7-day rest) in the disseminated leukemia model AmL-PS is well tolerated and clearly showed increased mice survival^[2]. NMS-P937 (60 mg/kg bid os per day over 2 days with a 5 day rest) shows good efficacy compared to standard therapies, with a significant increase in median survival time (MST) in the established disease setting^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

532.52

Formula

C₂₄H₂₇F₃N₈O₃

CAS No.

1034616-18-6

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=NN(CCO)C2=C1CCC3=CN=C(NC4=CC(N5CCN(C)CC5)=CC=C4OC(F)(F)F)N=C23)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

DMSO : 21 mg/mL (39.44 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8779 mL	9.3893 mL	18.7786 mL
5 mM	0.3756 mL	1.8779 mL	3.7557 mL
10 mM	0.1878 mL	0.9389 mL	1.8779 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2 mg/mL (3.76 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2 mg/mL (3.76 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2 mg/mL (3.76 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (281 KB) SDS (393 KB)

COA (249 KB) HNMR (141 KB) RP-HPLC (234 KB) MS (75 KB)

Handling Instructions (2659 KB)

References

[1]. Beria I, et al. NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor. Bioorg Med Chem Lett. 2011 May 15;21(10):2969-74. [Content Brief]

[2]. Valsasina B, et al. NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies. Mol Cancer Ther. 2012 Apr;11(4):1006-16. [Content Brief]

[3]. Casolaro A, et al. The Polo-Like Kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia. PLoS One. 2013;8(3):e58424. [Content Brief]

Kinase Assay ^[1]	The inhibitory activity of putative kinase inhibitors and the potency of selected compounds are determined using a trans-phosphorylation assay. Specific peptide or protein substrates are trans-phosphorylated by their specific serine-threonine or tyrosine kinase, in the presence of ATP traced with ³³P-γ-ATP, at optimized buffer and cofactors conditions. At the end of the phosphorylation reaction, more than 98% unlabeled ATP and radioactive ATP is captured by adding an excess of the ion exchange dowex resin; the resin then settles down to the bottom of the reaction plate by gravity. Supernatant, containing the phosphorylated substrate, is subsequently withdrawn and transferred into a counting plate, followed by evaluation by b-counting. Inhibitory potency evaluation for all the tested kinases is performed at 25°C using a 60 min end-point assay where the concentrations of ATP and substrates are kept equal to 2 × αK_m and saturated (>5 × αK_m), respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Assay ^[2]	Cells are seeded into 96- or 384-well plates at densities ranging from 10,000 to 30,000/cm² for adherent and 100,000/mL for nonadherent cells in appropriate medium supplemented with 10% fetal calf serum. After 24 hours, cells are treated in duplicate with serial dilutions of NMS-P937, and 72 hours later, the viable cell number is assessed by the CellTiter-Glo Assay. IC₅₀ values are calculated with a sigmoidal fitting algorithm. Experiments are carried out independently at least twice. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration ^[2]	For carcinoma xenograft studies, 5- to 6-week-old female Hsd, athymic nu/nu mice (average weight, 20-22 g), are used. HCT116, HT29, Colo205 colorectal, and A2780 ovarian human carcinoma cell lines are inoculated subcutaneously. Mice bearing a palpable tumor (100-200 mm³) are treated with vehicle or NMS-P937 following doses and schedules starting from the day after randomization. Tumor dimensions are measured regularly with Vernier calipers, and tumor growth inhibition (TGI) is calculated. Toxicity is evaluated on the basis of body weight reduction. For leukemia studies, 5- to 6-week-old female severe combined immunodeficient mice (SCID; average weight, 20-22 g) are used. The AmL cell line HL-60 (5×10⁶ cells) is injected subcutaneously and treatments initiated when tumor size reaches 200 to 250 mm³. Tumor dimensions and TGI are assessed. For disseminated models, 5×10⁶ AmL primary cells (AmL-PS) are injected intravenously and treatments start after 2 days. Mice are monitored daily for clinical signs of disease, and the median survival time is determined for each group. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Beria I, et al. NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor. Bioorg Med Chem Lett. 2011 May 15;21(10):2969-74. [Content Brief] [2]. Valsasina B, et al. NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies. Mol Cancer Ther. 2012 Apr;11(4):1006-16. [Content Brief] [3]. Casolaro A, et al. The Polo-Like Kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia. PLoS One. 2013;8(3):e58424. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8779 mL	9.3893 mL	18.7786 mL	46.9466 mL
	5 mM	0.3756 mL	1.8779 mL	3.7557 mL	9.3893 mL
	10 mM	0.1878 mL	0.9389 mL	1.8779 mL	4.6947 mL
	15 mM	0.1252 mL	0.6260 mL	1.2519 mL	3.1298 mL
	20 mM	0.0939 mL	0.4695 mL	0.9389 mL	2.3473 mL
	25 mM	0.0751 mL	0.3756 mL	0.7511 mL	1.8779 mL
	30 mM	0.0626 mL	0.3130 mL	0.6260 mL	1.5649 mL

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Onvansertib1034616-18-6NMS-1286937 NMS-P937NMS1286937NMS 1286937Polo-like Kinase (PLK)ApoptosisInhibitorinhibitorinhibit

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Onvansertib (Synonyms: NMS-1286937; NMS-P937)

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