1. PROTAC
  2. PROTAC Linker
  3. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD 

Cat. No.: HY-113697 Purity: 99.78%
Handling Instructions

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD Chemical Structure

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD Chemical Structure

CAS No. : 1037589-69-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 116 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 380 In-stock
Estimated Time of Arrival: December 31
50 mg USD 650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo
Animal Model: Eight week old Zucker rats[3]
Dosage: 3 mg/kg and 10 mg/kg
Administration: Subcutaneously twice a week for two weeks
Result: There was no change of BW observed, and food intake was not changed in the treated groups compared to control. Caused a significant decrease of glucose excursion during the oral glucose tolerance test (OGTT) compared to control.
Animal Model: 7-to-8-month-old Akita mice with type 1 diabete model[4]
Dosage: 10 mg/kg
Administration: Intraperitoneally injected; twice a week; for four weeks
Result: Administration improved retinal function in diabetic Akita mice.
Molecular Weight

528.55

Formula

C₂₆H₃₂N₄O₈

CAS No.

1037589-69-7

SMILES

O=C(CCN1C(C=CC1=O)=O)NCCOCCOCCC(NC2=CC=C(C=C2)CCC(N3C(CC3)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (236.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8920 mL 9.4598 mL 18.9197 mL
5 mM 0.3784 mL 1.8920 mL 3.7839 mL
10 mM 0.1892 mL 0.9460 mL 1.8920 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDPROTAC LinkerInhibitorinhibitorinhibit

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Product Name:
Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
Cat. No.:
HY-113697
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