2. Cardiovascular Disease

Cardiovascular Disease (心臓血管疾患)

Cardiovascular Disease

関連製品

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

製品番号 製品名 CAS 番号 純度 構造式
  • HY-103179
    SDZ-WAG994 130714-47-5 98%
    SDZ-WAG994 (WAG-994) is a stable, long-acting, selective and orally active A1-adenosine receptor agonist with a KD of 23 nM. SDZ-WAG994 can be used for the research of atrial fibrillation.
    SDZ-WAG994
  • HY-103202
    SNAP5089 hydrochloride 157066-77-8 98%
    SNAP5089 (hydrochloride) is a selective α1A adrenergic receptor antagonist. SNAP5089 (hydrochloride) can be used in the research of hypertension and benign prostatic hyperplasia.
    SNAP5089 hydrochloride
  • HY-103209
    Rec 15/2615 hydrochloride 173059-17-1 98%
    Rec 15/2615 hydrochloride is a potent and selective α-1B adrenoceptor antagonist with Ki values of 1.9 nM, 0.3 nM, 2.6 nM for α1A, α1B, α1D, respectively. Rec 15/2615 hydrochloride modulates vaginal smooth muscle contractility and genital engorgement.
    Rec 15/2615 hydrochloride
  • HY-103247
    EMD 66684 1216884-39-7 98%
    EMD 66684 is an antagonist of Angiotensin II Type 1 (AT1) receptor. EMD 66684 shows potent binding affinities for the AT1 subtype Ang II receptor with an IC50 value of 0.7 nM. EMD 66684 also serves as an antiischemic cytoprotectant -.
    EMD 66684
  • HY-103276
    Alytesin 31078-12-3 98%
    Alytesin, a bombesin-like peptide, is found in extracts of the skin of Alytes obstetricans. Alytesin reduces gastric acid secretion and induces hypertension. Alytesin also induces short-term anorexigenic effects in neonatal chicks
    Alytesin
  • HY-103292
    [Phe8Ψ(CH-NH)Arg9]-Bradykinin 118122-39-7 98%
    [Phe8Ψ(CH-NH)Arg9]-Bradykinin is a selective Bradykinin receptor B2 agonist (not cleaved by protein kinase I/II). [Phe8Ψ(CH-NH)Arg9]-Bradykinin has potential for the research of hypertension.
    [Phe8Ψ(CH-NH)Arg9]-Bradykinin
  • HY-103293
    Lys-Bradykinin 342-10-9 98%
    Lys-Bradykinin, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin involves in vascular regulation, inflammation and pain sensation.
    Lys-Bradykinin
  • HY-103313
    SR33805 oxalate 121346-33-6 98%
    SR33805 oxalate is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 oxalate blocks L-type but not T-type Ca2+ channels. SR33805 oxalate can be used for the research of acute or chronic failing hearts.
    SR33805 oxalate
  • HY-103459
    CI-1020 162256-50-0 98%
    CI-1020 (PD156707) is an orally active and selective antagonist targeting endothelin (ETA) with an IC50 value of 0.3 nM. CI-1020 blocks intimal hyperplasia in human saphenous veins completely in organ culture. CI 1020 inhibits hypoxic pulmonary hypertension and blocks ET-1-induced pressor responses following oral administration.
    CI-1020
  • HY-103653
    CKD-731 251111-15-6 98%
    CKD-731 is a Fumagillin (HY-B0751) analogue. CKD-731 inhibits the proliferation of calf pulmonary artery endothelial cells (CPAE), lymphoma EL-4 cells and murine leukemia P388D1 cells. CKD-731 exerts the effect of inhibiting MetAP-2 activity and blocking angiogenesis. CKD-731 can be used for the research of anti-angiogenesis-related cancer.
    CKD-731
  • HY-10419A
    AH23848 hemicalcium salt 81496-19-7
    AH23848 hemicalcium salt is an orally active, selective competitive blocker of the thromboxane A2 receptor, with an IC50 value of 50 nM. AH23848 hemicalcium salt shows no activity against other prostaglandin, serotonin (5-HT) or adenosine diphosphate (ADP) receptors. AH23848 hemicalcium salt can be used in the research of occlusive vascular diseases.
    AH23848 hemicalcium salt
  • HY-10427A
    iso-WAY-260022 1214914-38-1
    iso-WAY-260022 (Compound 13R) is an orally active, brain-penetrant and selective norepinephrine transporter (hNET) inhibitor with an IC50 value of 140 nM. iso-WAY-260022 also shows inhibitory effects on human serotonin (hSERT) and dopamine transporters (hDAT). iso-WAY-260022 inhibits norepinephrine reuptake and increases hypothalamic norepinephrine levels to regulate thermoregulatory center function. iso-WAY-260022 is promising for research of vasomotor symptoms, such as menopausal hot flushes, night sweats.
    iso-WAY-260022
  • HY-105020
    Derpanicate 99518-29-3 98%
    Derpanicate is a Nicotinic acid (HY-B0143) ester. Derpanicate has antihypercholesterolaemic and/or vasodilating effects.
    Derpanicate
  • HY-105057
    MDL 19205 84490-12-0 98%
    MDL 19205 is a cardiotonic agent with inotropic effect. MDL 19205 can be used for the research of cardiovascular disease, such as heart failure.
    MDL 19205
  • HY-105082
    Avitriptan 151140-96-4 98%
    Avitriptan is a 5-HT1B/1D receptor agonist, with pKis of 7.44 ( 5-HT1B rat), 7.68 ( 5-HT1B human) and 8.36 ( 5-HT1D human). Avitriptan constricts the isolated coronary artery. Avitriptan can be used for migraines.
    Avitriptan
  • HY-105111
    P-536 93426-60-9 98%
    P-536 is a ACE inhibitor that also inhibits herpes simplex virus HSV-1 thymidine kinase and Trypanosoma cruzi RNA polymerase. By inhibiting the renin-angiotensin system, downregulating the expression of AT1R and NOX4, and reducing oxidative stress (decreasing plasma hydrogen peroxide (H2O2) and 8-isoprostaglandin levels), P-536 effectively reduces systolic blood pressure and improves vascular reactivity. P-536 also inhibits the replication of DNA/RNA viruses such as HSV-1 by blocking nucleotide metabolism and nucleic acid synthesis, competitively inhibits RNA synthesis in Trypanosoma cruzi, and inhibits amastigote replication, thereby impeding its growth. P-536 is suitable for research on hypertension, insulin resistance, and Chagas disease.
    P-536
  • HY-105112
    Carmoxirole 98323-83-2 98%
    Carmoxirole (EMD 45609) is a selective, peripherally acting dopamine D2 receptor agonist and exhibits antihypertensive activities in vivo.
    Carmoxirole
  • HY-105135
    15-Deoxy-16-hydroxy-16-vinyl-PGE2 Me ester 73621-92-8 98%
    15-Deoxy-16-hydroxy-16-vinyl-PGE2 Me ester is the (R,R,R)-isomer of Viprostol (HY-105135A) and a PGE2 analogue with antihypertensive property. 15-Deoxy-16-hydroxy-16-vinyl-PGE2 Me ester can be utilized in cardiovascular disease research.
    15-Deoxy-16-hydroxy-16-vinyl-PGE2 Me ester
  • HY-105138
    (6R)-Naxifylline 166374-48-7 98%
    (6R)-Naxifylline ((6R)-BG9719) (ENX R-enantiomer) is the R-enantiomer of Naxifylline (HY-19240). (6R)-Naxifylline is a A1-adenosine antagonist with saluretic activity. (6R)-Naxifylline induces relaxation of spontaneous tone in guinea pig trachea.
    (6R)-Naxifylline
  • HY-105154
    Proxodolol free base 152289-58-2 98%
    Proxodolol free base is a β-adrenergic receptor blocker. Proxodolol free base can be used for the study of arterial hypertension.
    Proxodolol free base
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