2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P10309
    [Nle8,18,Tyr34]-pTH (3-34) amide (human) 120527-89-1 98%
    [Nle8,18,Tyr34]-pTH (3-34) amide human ([Nle8,18,Tyr34]hPTH (3-34) amide) is a parathyroid hormone (PTH) analog.
    [Nle8,18,Tyr34]-pTH (3-34) amide (human)
  • HY-P10318
    SHR-2042 98%
    SHR-2042 is a selective agonist of the GLP-1 receptor.SHR-2042 improves glycemic control by activating the GLP-1 receptor, enhancing insulin secretion and inhibiting glucagon secretion. SHR-2042 combined with sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC) promotes monomerization through the formation of micelles and improves oral absorption efficiency.
    SHR-2042
  • HY-P1032F
    Biotinyl-Angiotensin I (human, mouse, rat) 1815618-04-2 98%
    Biotinyl-Angiotensin I (human, mouse, rat) is biotin-labeled Angiotensin I . Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).
    Biotinyl-Angiotensin I (human, mouse, rat)
  • HY-P10337
    OXM-7 98%
    OXM-7 is a dual agonist of GLP-1R (EC50=0.024 nM) and GCGR (EC50=0.082 nM). OXM-7 can enhance glucose-stimulated insulin secretion and hepatic glucose output. OXM-7 lowers blood glucose levels. OXM-7 improves lipid metabolism.
    OXM-7
  • HY-P10472
    Azaline B 134457-28-6 98%
    Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception.
    Azaline B
  • HY-P10572
    HG1 Toxin 98%
    HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (Ki=107 nM) and can be used in the study of autoimmune diseases.
    HG1 Toxin
  • HY-P10594
    Myr-Arf1(2–17) 143244-89-7 98%
    Myr-Arf1(2–17) is a sarcosinated peptide that mimics the localization and function of Arf1 protein on the cell membrane. Myr-Arf1(2–17) can be used to study the desensitization mechanism of luteinizing hormone/chorionic gonadotropin receptor (LH/CGR).
    Myr-Arf1(2–17)
  • HY-P10780
    RFRP-3 (mouse) 98.82%
    RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development.
    RFRP-3 (mouse)
  • HY-P10806
    kCAL01 1364717-03-2 98%
    kCAL01 is a CAL inhibitor with a Ki value of 2.3 μM. kCAL01 is promising for research of cystic fibrosis (CF).
    kCAL01
  • HY-P10964
    Tezusomant 2802416-72-2 98%
    Tezusomant is a growth hormone receptor antagonist. Tezusomant is promising for research on diseases caused by excessive growth hormone secretion, such as acromegaly.
    Tezusomant
  • HY-P11164
    PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA
    PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA is a peptide. PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA has a higher affinity for CR3 and DNA binding domain than FOXO4 and DRI. PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA can be used in the research of aging.
    PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA
  • HY-P11238
    Filimelnotide 2093087-54-6
    Filimelnotide is a agonist of melanocortin receptor.
    Filimelnotide
  • HY-P11278
    Federelin 57521-78-5 98%
    Federelin (Gonadorelin[6-D-Phe]) is a gonadotropin (GnRH) analog.
    Federelin
  • HY-P11291
    NNC0165-1273 98%
    NNC0165-1273 is an analog of gut hormone peptide YY (PYY3-36). NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research.
    NNC0165-1273
  • HY-P11362
    δ-MSH 100930-04-9
    δ-MSH is a melanocortin peptide. δ-MSH is a weak melanocortin receptor (MCRs) ligand.
    δ-MSH
  • HY-P11452
    (KKEEE)3K 1637464-75-5 98%
    (KKEEE)3K is a kidney-targeting peptide. (KKEEE)3K enters renal tubular cells via megalin receptor-mediated endocytosis. (KKEEE)3K can be used in the research of renal drug delivery.
    (KKEEE)3K
  • HY-P11738
    Murine ZP3 peptide (330-342) 152439-29-7 98.76%
    Murine ZP3 peptide (330-342) is a zona pellucida 3 polypeptide fragment with the amino acid sequence NSSSSQFQIHGPR. Murine ZP3 peptide (330-342) induces autoimmune premature ovarian failure (POF). Murine ZP3 peptide (330-342) can be used for the research of premature ovarian failure.
    Murine ZP3 peptide (330-342)
  • HY-P11832
    CaSR agonist peptide-1 3057162-39-4
    CaSR agonist peptide-1 is a human calcium-sensing receptor (CaSR) agonist. CaSR agonist peptide-1 activates CaSR by binding to it. CaSR agonist peptide-1 can be used in studies related to secondary hyperparathyroidism.
    CaSR agonist peptide-1
  • HY-P1183A
    Locustatachykinin I TFA 98%
    Locustatachykinin I TFA is a insect tachykinin-related peptide isolated from Locusta migratoria. Locustatachykinin I TFA exhibits sequence homologies with the vertebrate tachykinins. In Lacanobia, Locustatachykinin I TFA is also a substrate for a deamidase.
    Locustatachykinin I TFA
  • HY-P11879
    LSALT peptide 2567713-50-0 98%
    LSALT peptide is a selective DPEP-1 inhibitor with selectivity over DPEP2/3. LSALT peptide inhibits neutrophil and monocyte/macrophage recruitment, inflammation, and tissue injury. LSALT peptide reduces kidney damage, improves survival in murine sepsis and endotoxemia models. LSALT peptide can be used for the research of COVID-19, sepsis, acute respiratory distress syndrome, and acute kidney injury.
    LSALT peptide
Cat. No. Product Name / Synonyms Application Reactivity