Murine ZP3 peptide (330-342)
Based on 1 Customer Validation
Murine ZP3 peptide (330-342) is a zona pellucida 3 polypeptide fragment with the amino acid sequence NSSSSQFQIHGPR. Murine ZP3 peptide (330-342) induces autoimmune premature ovarian failure (POF). Murine ZP3 peptide (330-342) can be used for the research of premature ovarian failure.
For research use only. We do not sell to patients.
- Purity : 98.76%
- CAS No.: 152439-29-7
- Formula: C60H93N21O21
- Molecular Weight:1444.51
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vivo
in complete Freund’s adjuvant (CFA) (HY-153808)) (50 nmol/L; s.c.; the second injection at an interval of 7 days (emulsified
in incomplete Freund’s adjuvant (IFA) (HY-153808A))) reliably induces premature ovarian failure in female Balb/c mice, as evidenced by disrupted serum hormone and cytokine profiles, altered ovarian and uterine morphology, reduced endometrial receptivity markers, and perturbed local immune cell populations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c (female, 8 weeks old)[1]
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Dosage:50 nmol/L
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Administration:s.c.; two injections 7 days apart; (emulsified
in complete Freund’s adjuvant (CFA) and incomplete Freund’s adjuvant (IFA) -
Result:Increased serum follicle stimulating hormone (FSH), interferon-γ (IFN-γ), and interleukin-2 (IL-2) levels.
Decreased serum estradiol (E2), progesterone (P), and interleukin-4 (IL-4) levels.
Increased percentage of uterine CD56+CD16- uterine natural killer (uNK) cells.
Elevated splenic IFN-γ expression and reduced splenic IL-4 expression.
Reduced ovarian mass, induced abnormal ovarian structure, interstitial hyperplasia, severe fibrosis, decreased number of functional ovarian follicles, and increased number of atretic follicles.
Impaired endometrial development with reduced blood vessels and gland numbers.
Decreased endometrial HOXA10 protein and mRNA expression.
Reduced number of endometrial epithelial pinopodes with irregular morphology.
Increased endometrial CD56 and IFN-γ expression with decreased IL-4 expression.
Chemical Information
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CAS No. 152439-29-7
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Appearance Solid
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Molecular Weight 1444.51
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Formula C60H93N21O21
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Color White to off-white
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Sequence
Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln-Ile-His-Gly-Pro-Arg
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Sequence Shortening
NSSSSQFQIHGPR
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (69.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Lu X, et al. The effects of human umbilical cord-derived mesenchymal stem cell transplantation on endometrial receptivity are associated with Th1/Th2 balance change and uNK cell expression of uterine in autoimmune premature ovarian failure mice. Stem Cell Res Ther. 2019;10(1):214. Published 2019 Jul 22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6923 mL | 3.4614 mL | 6.9228 mL | 17.3069 mL |
| 5 mM | 0.1385 mL | 0.6923 mL | 1.3846 mL | 3.4614 mL | |
| 10 mM | 0.0692 mL | 0.3461 mL | 0.6923 mL | 1.7307 mL | |
| 15 mM | 0.0462 mL | 0.2308 mL | 0.4615 mL | 1.1538 mL | |
| 20 mM | 0.0346 mL | 0.1731 mL | 0.3461 mL | 0.8653 mL | |
| 25 mM | 0.0277 mL | 0.1385 mL | 0.2769 mL | 0.6923 mL | |
| 30 mM | 0.0231 mL | 0.1154 mL | 0.2308 mL | 0.5769 mL | |
| 40 mM | 0.0173 mL | 0.0865 mL | 0.1731 mL | 0.4327 mL | |
| 50 mM | 0.0138 mL | 0.0692 mL | 0.1385 mL | 0.3461 mL | |
| 60 mM | 0.0115 mL | 0.0577 mL | 0.1154 mL | 0.2884 mL |
Murine ZP3 peptide (330-342) Related Classifications
HY-P11738 Related Classifications
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