2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W704363
    Pimozide-d5 1794979-08-0 98%
    Pimozide-d5 (R6238-d5) is the deuterium labeled Pimozide (HY-12987). Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
    Pimozide-d5
  • HY-W710827
    N,N'-Methylenebisacrylamide-d6 98%
    N,N'-Methylenebisacrylamide-d6 is the deuterium labeled N,N'-Methylenebisacrylamide (HY-D0848). N,N'-Methylenebisacrylamide (Bisacrylamide) is an orally active acrylamide dimer and crosslinker. N,N'-Methylenebisacrylamide increases CYP2E1, P53, cleaved caspase-3. N,N'-Methylenebisacrylamide promotes hepatic cancer. N,N'-Methylenebisacrylamide changes sperm abnormality rate and sperm count. N,N'-Methylenebisacrylamide decreases the number of various cells in the blood as well as induces liver and testicular damage. N,N'-Methylenebisacrylamide is used to prepare polyacrylamide gel.
    N,N'-Methylenebisacrylamide-d6
  • HY-W724254
    SNAP-6201 252201-38-0 98%
    SNAP-6201 is a selective α1a adrenoceptor antagonist with a Ki of 0.2 nM. SNAP-6201 exhibits >1400-fold selectivity over α1b and α1d adrenoceptors. SNAP-6201 exhibits excellent selectively to inhibit intraurethral pressure (IUP) in the anesthetized dog model. SNAP-6201 can be used for benign prostatic hyperplasia (BPH) research.
    SNAP-6201
  • HY-W728545
    Labetalol-d6 hydrochloride 98%
    Labetalol hydrochloride-d6 (AH-5158 hydrochloride-d6) is deuterium labeled Labetalol hydrochloride (HY-B1108). Labetalol (AH5158) hydrochloride is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy.
    Labetalol-d6 hydrochloride
  • HY-W740212
    16-Keto 17Beta-estradiol-d5 98%
    16-Keto 17Beta-estradiol-d5 is the deuterium labeled 16-Ketoestradiol (HY-W587691). 6-Ketoestradiol is an active metabolite of the endogenous estrogen estrone.
    16-Keto 17Beta-estradiol-d5
  • HY-W740360
    Daidzein-3',5',8-d3 220930-96-1 98%
    Daidzein-3',5',8-d3 is the deuterium labeled Daidzein (HY-N0019). Daidzein is a soy isoflavone, which acts as a PPAR activator.
    Daidzein-3',5',8-d3
  • HY-W740773
    Betamethasone-d10 Dipropionate 98%
    Betamethasone-d10 Dipropionate is the deuterium labeled Betamethasone dipropionate (HY-13571). Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.
    Betamethasone-d10 Dipropionate
  • HY-W743417
    (-)-Norgestrel-d6 98%
    (-)-Norgestrel-d6 is the deuterium labeled Levonorgestrel (HY-B0257). Levonorgestrel is an orally active inhibitor of progesterone (HY-N0437). Levonorgestrel has anticancer activity and can induce Apoptosis. Levonorgestrel can be used as a contraceptive and in combination with other medications. Levonorgestrel can be used in the study of osteoporosis and uterine leiomyoma.
    (-)-Norgestrel-d6
  • HY-W744187
    Clobetasol 17-Propionate-d5 2280940-18-1 98%
    Clobetasol 17-Propionate-d5 is the deuterium labeled Clobetasol propionate (HY-13600). Clobetasol propionate is a potent and selective CYP3A5 inhibitor with an IC50 of 0.206 μM. Clobetasol propionate has no inhibiting on CYP3A4 or other major CYPs. Clobetasol propionate is a corticosteroid and has the potential for psoriasis and other dermatoses research.
    Clobetasol 17-Propionate-d5
  • HY-W744206
    Azelastine-d3 758637-88-6 98%
    Azelastine-d3 is the deuterium labeled Azelastine (HY-B0462A). Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.
    Azelastine-d3
  • HY-W745855
    Androstatrione 100024-35-9 98%
    Androstatrione is an androgenic compound.
    Androstatrione
  • HY-W745905
    2'-Deoxyadenosine-15N1 106568-85-8 98%
    2'-Deoxyadenosine-15N1 is the 15N-labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
    2'-Deoxyadenosine-15N1
  • HY-W746582
    Norethindrone-d7 98%
    Norethindrone-d7 (Norethisterone-d7) is the deuterium labeled Norethindrone (HY-B0554). Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea.
    Norethindrone-d7
  • HY-W746761
    Cyclodiol 116229-13-1 98%
    Cyclodiol is an estrogen. Cyclodiol is used for fertility control in females and also as oral contraceptives in combination with a variety of progestins.
    Cyclodiol
  • HY-W746807
    Bimatoprost cyclohexyl amide 98%
    Bimatoprost cyclohexyl amide (N-Cyclohexyl-desamethyl bimatoprost; 17-Phenyl trinor prostaglandin F2α cyclohexyl amide) is an analog of bimatoprost (HY-B0191). Bimatoprost cyclohexyl amide is an agonist of the prostaglandin F2α receptor. Bimatoprost cyclohexyl amide is used in research on reducing intraocular pressure and glaucoma.
    Bimatoprost cyclohexyl amide
  • HY-W749562
    Gossyplure 50933-33-0 98%
    Gossyplure is an insect pheromone used for capturing male pink bollworm moths and corn earworms.
    Gossyplure
  • HY-W749649
    Neomenthoglycol 3564-95-2 98%
    Neomenthoglycol (8-Hydroxyneomenthol) (2) is a monoterpene compound isolated from finger lime.
    Neomenthoglycol
  • HY-W752724
    Flunisolide-d4 98%
    Flunisolide-d4 is the deuterium labeled Flunisolide (HY-B1121). Flunisolide is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation.
    Flunisolide-d4
  • HY-W753897
    Gestodene-d7 98%
    Gestodene-d7 is the deuterium labeled Gestodene (HY-B0110). Gestodene is a progestin-based contraceptive. Gestodene is a click chemistry reagent. It contains an alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an azide group.
    Gestodene-d7
  • HY-W755511
    Lodoxamide-15N2,d2 2733832-83-0 98%
    Lodoxamide-15N2,d2 (U-42585E (free acid)-15N2,d2) is the deuterium and 15N-labeled Lodoxamide (HY-14270). Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.
    Lodoxamide-15N2,d2
Cat. No. Product Name / Synonyms Application Reactivity