2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-100856R
    PCO371 (Standard) 1613373-33-3 98%
    PCO371 (Standard) is the analytical standard of PCO371 (HY-100856). This product is intended for research and analytical applications. PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.
    PCO371 (Standard)
  • HY-101022R
    CXCR2-IN-1 (Standard) 1873376-49-8 98%
    CXCR2-IN-1 (Standard) is the analytical standard of CXCR2-IN-1 (HY-101022). This product is intended for research and analytical applications. CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonist with a pIC50 of 9.3.
    CXCR2-IN-1 (Standard)
  • HY-101086R
    Acetylcholine iodide (Standard) 2260-50-6 98%
    Acetylcholine (iodide) (Standard) is the analytical standard of Acetylcholine (iodide). This product is intended for research and analytical applications. Acetylcholine iodide (ACh iodide) is a common neurotransmitter found in the central and peripheral nerve system.
    Acetylcholine iodide (Standard)
  • HY-101189R
    JNJ-39758979 (Standard) 1046447-90-8 98%
    JNJ-39758979 (Standard) is the analytical standard of JNJ-39758979 (HY-101189). This product is intended for research and analytical applications. JNJ-39758979, a chemical probe, is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity.
    JNJ-39758979 (Standard)
  • HY-101217R
    BI 689648 (Standard) 1633009-87-6 98%
    BI 689648 (Standard) is the analytical standard of BI 689648 (HY-101217). This product is intended for research and analytical applications. BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively.
    BI 689648 (Standard)
  • HY-10121S4
    Asenapine-d3,13C 1217729-73-1 98%
    Asenapine-d3,13C (Org 5222-d3,13C) is deuterium and 13C labeled Asenapine. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.
    Asenapine-d3,13C
  • HY-101336R
    RS 17053 hydrochloride (Standard) 169505-93-5 98%
    RS 17053 hydrochloride (Standard) is the analytical standard of RS 17053 hydrochloride (HY-101336). This product is intended for research and analytical applications. RS 17053 hydrochloride is a potent and selective α1A adrenoceptor antagonist, with a pKi value of 9.1 in native cell membrane and a pA2 value of 9.8 in functional assays.
    RS 17053 hydrochloride (Standard)
  • HY-101385R
    L-765314 (Standard) 189349-50-6 98%
    L-765314 (Standard) is the analytical standard of L-765314 (HY-101385). This product is intended for research and analytical applications. L-765314 is a potent and selective α1b adrenergic receptor antagonist with Kis of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.
    L-765314 (Standard)
  • HY-101420R
    VUF10460 (Standard) 1028327-66-3 98%
    VUF10460 (Standard) is the analytical standard of VUF10460 (HY-101420). This product is intended for research and analytical applications. VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46.
    VUF10460 (Standard)
  • HY-101534R
    GSK1059865 (Standard) 1191044-58-2 98%
    GSK1059865 (Standard) is the analytical standard of GSK1059865 (HY-101534). This product is intended for research and analytical applications. GSK1059865 is a potent orexin 1 receptor antagonist.
    GSK1059865 (Standard)
  • HY-101658A
    Pargolol 47082-97-3 98%
    Pargolol is a β adrenergic receptor antagonist.
    Pargolol
  • HY-101713R
    Ilacirnon (Standard) 1100318-47-5 98%
    Ilacirnon (Standard) is the analytical standard of Ilacirnon. This product is intended for research and analytical applications. CCX140 (CCX140-B) is a potent CCR2 antagonist.
    Ilacirnon (Standard)
  • HY-101752A
    (±)-Befunolol hydrochloride 39543-79-8 98%
    (±)-Befunolol hydrochloride is a β-adrenoceptor blocking agent.
    (±)-Befunolol hydrochloride
  • HY-101755R
    Tedatioxetine hydrobromide (Standard) 960151-65-9 98%
    Tedatioxetine hydrobromide (Standard) (Lu AA24530 hydrobromide (Standard)) is the analytical standard of Tedatioxetine hydrobromide (HY-101755). This product is intended for research and analytical applications. Tedatioxetine (Lu AA24530) hydrobromide acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist. ,
    Tedatioxetine hydrobromide (Standard)
  • HY-101830R
    Wy 49051 (Standard) 113418-56-7 98%
    Wy 49051 (Standard) is the analytical standard of Wy 49051 (HY-101830). This product is intended for research and analytical applications. Wy 49051 is a potent, orally active H1 receptor antagonist, with IC50 of 44 nM.
    Wy 49051 (Standard)
  • HY-101877R
    Statine (Standard) 49642-07-1 98%
    Statine (Standard) is the analytical standard of Statine. This product is intended for research and analytical applications. Statine is an unusual amino acid that occurs twice in the sequence of pepstatin, a protease inhibitor that is active against pepsin and other acid proteases.
    Statine (Standard)
  • HY-101908R
    BMS CCR2 22 (Standard) 445479-97-0 98%
    BMS CCR2 22 (Standard) is the analytical standard of BMS CCR2 22 (HY-101908). This product is intended for research and analytical applications. BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist with excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM).
    BMS CCR2 22 (Standard)
  • HY-101986R
    BIIE-0246 (Standard) 246146-55-4 98%
    BIIE-0246 (Standard) is the analytical standard of BIIE-0246 (HY-101986). This product is intended for research and analytical applications. BIIE-0246 (AR-H 053591) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy.
    BIIE-0246 (Standard)
  • HY-101987R
    BW 245C (Standard) 72814-32-5 98%
    BW 245C (Standard) is the analytical standard of BW 245C (HY-101987). This product is intended for research and analytical applications. BW 245C is a prostanoid DP-receptor (DP1) agonist, used to treat stroke.
    BW 245C (Standard)
  • HY-102032R
    Butyryltimolol (Standard) 106351-79-5 98%
    Butyryltimolol (Standard) is the analytical standard of Butyryltimolol (HY-102032). This product is intended for research and analytical applications. Butyryltimolol, an effective precursor of Timolol, improves the corneal penetration of Timolol. Butyryltimolol is a β-adrenergic blocker.
    Butyryltimolol (Standard)
Cat. No. Product Name / Synonyms Application Reactivity