2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W108649
    (R)-1-Amino-3-chloropropan-2-ol hydrochloride 34839-14-0
    (R)-1-Amino-3-chloropropan-2-ol hydrochloride is a derivative of 3-chloro-l,2 propanediol (α-chlorohydrin). 3-chloro-l,2 propanediol (a-chlorohydrin) is a male chemosterilant.
    (R)-1-Amino-3-chloropropan-2-ol hydrochloride
  • HY-W241255
    2-Aminoindan-2-carboxylic acid 27473-62-7 98%
    2-Aminoindan-2-carboxylic acid is a conformationally restricted Phenylalanine analog and molecular building block. 2-Aminoindan-2-carboxylic acid constitutes a component of allosteric LFA-1 antagonists targeting the LFA-1/ICAM-1 interaction. 2-Aminoindan-2-carboxylic acid serves as a molecular building block for various biologically active peptides, including μ-receptor-selective opioid analogs, activated protein C inhibitors, and histone deacetylase inhibitors. 2-Aminoindan-2-carboxylic acid can be used in the research of autoimmune diseases, inflammatory diseases, opioid receptor-related diseases, antidiuresis-related diseases, and cancers.
    2-Aminoindan-2-carboxylic acid
  • HY-W267205
    3-Acetyl-7-Hydroxycoumarin 10441-27-7
    3-Acetyl-7-Hydroxycoumarin (Compound 2) is a high selective 17-beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor. 3-Acetyl-7-Hydroxycoumarin shows a significant improvement of the inhibitory potency, with 57% inhibition of 17β-HSD1 at 6 μM. 3-Acetyl-7-Hydroxycoumarin is promising for research of hormone-dependent diseases, such as breast cancer and endometriosis.
    3-Acetyl-7-Hydroxycoumarin
  • HY-W585982
    Bisphenol A-β-D-glucuronide 267244-08-6 99.62%
    Bisphenol A-β-D-glucuronide is an inactive metabolite of the plasticizer Bisphenol A (HY-18260).
    Bisphenol A-β-D-glucuronide
  • HY-W653723
    N-Nitrosodicyclohexylamine 947-92-2 ≥99.0%
    N-Nitrosodicyclohexylamine (NDCHA) is a N-nitrosocompound with anti-androgenic activities. N-Nitrosodicyclohexylamine shows the competitive binding to androgen receptor (AR) against 5α-dihydrotestosterone and decreased the level of AR protein.
    N-Nitrosodicyclohexylamine
  • HY-W662576
    KVD-001 1417691-95-2 99.73%
    KVD-001 is a potent plasma kallikrein inhibitor. KVD-001 can be used for diabetic macular edema research.
    KVD-001
  • HY-W777677
    Bisphenol b-D-glucuronide A-d6 1610029-53-2 98%
    Bisphenol b-D-glucuronide A-d6 is the deuterium labeled Bisphenol A-β-D-glucuronide (HY-W585982). Bisphenol A-β-D-glucuronide is an inactive metabolite of the plasticizer Bisphenol A (HY-18260).
    Bisphenol b-D-glucuronide A-d6
  • HY-Y1217S1
    1-Cyclohexanol-d11 93131-17-0 98%
    1-Cyclohexanol11 (Hydroxycyclohexane11; NSC 5471111) is the deuterium labeled 1-Cyclohexanol (HY-Y1217). 1-Cyclohexanol is an orally active Cramer Class I flavor ingredient that can be used in fragrances. 1-Cyclohexanol has a wide margin of safety and is environmentally friendly.
    1-Cyclohexanol-d11
  • HY-101952S1
    Prostaglandin E2-d9 1356347-42-6 99.5%
    Prostaglandin E2-d9 is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
    Prostaglandin E2-d9
  • HY-141901S1
    DHEA-d5 97453-25-3 98%
    DHEA-d5 (Prasterone-d5; Dehydroisoandrosterone-d5; Dehydroepiandrosterone-d5) is the deuterium labeled DHEA (HY-14650). DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.
    DHEA-d5
  • HY-A0070AS2
    Liothyronine-13C6-1 1213431-76-5 98.06%
    Liothyronine-13C6-1 is a 13C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
    Liothyronine-13C6-1
  • HY-B0524AS1
    Betahistine-13C,d3 dihydrochloride 98%
    Betahistine-13C,d3 (dihydrochloride) is the 13C- and deuterium labeled Betahistine (dihydrochloride). Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA).
    Betahistine-13C,d3 dihydrochloride
  • HY-W001160R
    5-Hydroxyindole (Standard) 1953-54-4 98%
    5-Hydroxyindole (Standard) is the analytical standard of 5-Hydroxyindole (HY-W001160). This product is intended for research and analytical applications. 5-Hydroxyindole is an orally active hydroxylated indole and tryptophan metabolite. 5-Hydroxyindole activates α7 nicotinic acetylcholine receptors and acts on intestinal L-type calcium channels. 5-Hydroxyindole slows down the desensitization of 5-HT3 receptor-mediated ion currents in cells. 5-Hydroxyindole causes convulsions and loss of consciousness. 5-Hydroxyindole is used in the study of neuroblastoma, schizophrenia, and diseases related to intestinal motility disorders.
    5-Hydroxyindole (Standard)
  • HY-W017158R
    Melilotic acid (Standard) 495-78-3 99.92%
    Melilotic acid (Standard) is an analytical standard for Melilotic acid (HY-W017158). This product is intended for research and analytical applications. Melilotic acid (3-(2-hydroxyphenyl)-propanoic acid) is an orally active compound. Melilotic acid can be isolated from the bark of Chinese cinnamon. Melilotic acid has a significant inhibitory effect on gastric ulcers induced by serotonin (HY-B1473A), phenylbutazone (HY-B0230), ethanoyl, and water immersion stress.
    Melilotic acid (Standard)
  • HY-12301
    MK-3697 1224846-01-8 98.83%
    MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.
    MK-3697
  • HY-12339
    NVS-CRF38 1207258-55-6 98%
    NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility.
    NVS-CRF38
  • HY-13673
    Goserelin 65807-02-5 98%
    Goserelin (ICI 118630), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer.
    Goserelin
  • HY-13995
    Sevelamer 52757-95-6 98%
    Sevelamer is an orally active polymeric phosphate binder and bile acid sequestrant. Sevelamer binds dietary phosphate in the gastrointestinal tract, reducing phosphate absorption and serum phosphorus levels, and reduces urinary phosphate excretion. Sevelamer binds polyanion bile acids, increases bile acid faecal excretion, and reduces total cholesterol and LDL cholesterol levels. Sevelamer can be used for the research of hyperphosphataemia, hyperparathyroidism, chronic renal failure, kidney disease, and type 2 diabetes.
    Sevelamer
  • HY-15394
    (Rac)-Rotigotine hydrochloride 102120-99-0 98.11%
    (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
    (Rac)-Rotigotine hydrochloride
  • HY-15450
    INCB 3284 dimesylate 887401-93-6 ≥98.0%
    INCB 3284 dimesylate is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 dimesylate can be used in the research of acute liver failure.
    INCB 3284 dimesylate
Cat. No. Product Name / Synonyms Application Reactivity