2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-139839
    Y12196 1671025-91-4 98%
    Y12196 is a novel succinate dehydrogenase inhibitor (SDHI) which exhibits strong fungicidal activity against F. graminearum.
    Y12196
  • HY-139845
    Antiviral agent 9 98%
    Antiviral agent 9 reaches a single-digit picomolar EC50 value (0.006 nM) against HIV-1 and nearly 300-fold higher selectivity index (SI) compared to tenofovir alafenamide fumarate (TAF).
    Antiviral agent 9
  • HY-139850
    GPS491 2655502-29-5 98%
    GPS491 (EC50 = 0.47 μM) suppresses expression of the HIV-1 structural protein Gag and alters HIV-1 RNA accumulation, decreasing the abundance of RNAs encoding the structural proteins while increasing levels of viral RNAs encoding the regulatory proteins.
    GPS491
  • HY-139851
    Fungicide5 2344721-61-3 98%
    Fungicide5 is a fungicide candidate targeting succinate dehydrogenase (Ki = 0.095 μM).
    Fungicide5
  • HY-139863
    Antibacterial agent 62 3031364-03-8 98%
    Antibacterial agent 62 is a novel redox cycling antituberculosis chemotype with potent bactericidal activity against growing and nutrient-starved phenotypically drug-resistant nongrowing bacteria.
    Antibacterial agent 62
  • HY-139866
    SARS-CoV-2-IN-9 1453052-57-7 98%
    SARS-CoV-2-IN-9 is an inhibitor binding to subsites S1 and S2 in SARS-CoV-2 main protease.
    SARS-CoV-2-IN-9
  • HY-139887
    Antibacterial agent 63 2910919-43-4 98%
    Antibacterial agent 63, a conjugate of aztreonam to a siderophore mimetic, shows activity against gram-negative bacteria.
    Antibacterial agent 63
  • HY-139892
    XR8-69 2817811-10-0 98%
    XR8-69 is a SARS-CoV-2 PLpro inhibitor that shows low micromolar antiviral potency in SARS-CoV-2-infected human cells.
    XR8-69
  • HY-139900
    Benzyl 2-hydroxy-6-methoxybenzoate 24474-71-3 98%
    Benzyl 2-hydroxy-6-methoxybenzoate shows the strongest antifungal effect, with IC50 of 25–26 μg/mL for both fungal strains.
    Benzyl 2-hydroxy-6-methoxybenzoate
  • HY-139905
    Antifungal agent 19 98%
    Antifungal agent 19 shows the potent antifungal activity (EC50 = 0.72 μM).
    Antifungal agent 19
  • HY-139971
    Antibacterial agent 64 618865-52-4 98%
    Antibacterial agent 64 (compound 62) is a potent YycG inhibitor (IC50=6.1 µM) and an antibacterial agent. Antibacterial agent 64 combines with ampicillin could synergistically eradicate the biofilm-embedded viable bacteria.
    Antibacterial agent 64
  • HY-139987
    LeuRS-IN-1 1364914-72-6 98%
    LeuRS-IN-1 is a potent, orally active M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS) inhibitor. LeuRS-IN-1 has IC50 and Kd values of 0.06 μM, 0.075 μM for M.tb LeuRS, respectively. LeuRS-IN-1 inhibits human cytoplasmic LeuRS (IC50=38.8 μM), and HepG2 protein synthesis (EC50=19.6 μM).
    LeuRS-IN-1
  • HY-139991
    Neuraminidase-IN-3 2699874-41-2 98%
    Neuraminidase-IN-3 (compound 23d) is a potent influenza neuraminidase (NA) inhibitor with IC50 values of 0.73, 0.26, and 0.63 nM against H1N1, H5N1, and H5N8 NAs, respectively.
    Neuraminidase-IN-3
  • HY-141426
    MDL-860 78940-62-2 98%
    MDL-860 is a broad-spectrum antipicornavirus compound that has low cytotoxicity toward human cells. MDL-860 can be used for the research of virus infection.
    MDL-860
  • HY-141442
    Dihydronovobiocin 29826-16-2 98%
    Dihydronovobiocin is a bacterial inhibitor and ATPase inhibitor that can bind to GyrB. Dihydronovobiocin can be used to study the interaction between coumarin antibiotics (such as Novobiocin, Chlorobiocin, and Coumermycin) and DNA gyrase. Dihydronovobiocin also has the potential to study bacterial infections.
    Dihydronovobiocin
  • HY-141456
    Tetramethylfluthrin 84937-88-2 98%
    Tetramethylfluthrin is an insecticide with potent activity against Aedes albopictus. Tetramethylfluthrin contributes to rapid Aedes albopictus population reduction when deployed via unmanned aerial vehicle cold mist spray. Tetramethylfluthrin exerts a knock-down effect and exhibits high toxicity to target insects. Tetramethylfluthrin can be used for the research of dengue fever and dengue hemorrhagic fever.
    Tetramethylfluthrin
  • HY-141535
    IL-17 modulator 1 2446803-85-4 98%
    IL-17 modulator 1 is an orally active, highly efficacious small molecule IL-17 modulators extracted from patent WO 2020127685. IL-17 modulator 1 can be used for the research of preventing, researching or ameliorating a variety of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis.
    IL-17 modulator 1
  • HY-141621
    ACT-606559 98%
    ACT-606559, a new chemical entity with antimalarial activity, is a metabolite of ACT451840. ACT-606559 can be used for the research of malarial.
    ACT-606559
  • HY-141648
    Antibacterial agent 219 1649473-91-5 98%
    Antibacterial agent 219 (Compound 2/75c) exhibits antibacterial activity by targeting cell wall biosynthesis. Antibacterial agent 219 inhibits methicillin-resistant Staphylococcus aureus (MRSA) strains (MIC=0.5-32 µg/mL), Enterococcus faecium (MIC=2 µg/mL) and S. aureus (MIC=2 µg/mL).
    Antibacterial agent 219
  • HY-141717
    α-cis-Bergamotene 18252-46-5 98%
    α-cis-Bergamotene is a sesquiterpene compound. α-cis-Bergamotene exhibits no antennal activity.
    α-cis-Bergamotene
Cat. No. Product Name / Synonyms Application Reactivity